Methyl alpha-methyl-4-morpholinepropionate

Base Information

• Chemical Name: Methyl alpha-methyl-4-morpholinepropionate
• CAS No.: 20120-26-7
• Deprecated CAS: 35806-18-9
• Molecular Formula: C9H17NO3
• Molecular Weight: 187.239
• Hs Code.: 2934999090
• European Community (EC) Number: 243-527-3
• DSSTox Substance ID: DTXSID50893282
• Nikkaji Number: J257.402K
• Mol file: 20120-26-7.mol

Synonyms:20120-26-7;Methyl 2-methyl-3-morpholinopropanoate;Methyl alpha-methyl-4-morpholinepropionate;methyl 2-methyl-3-morpholin-4-ylpropanoate;EINECS 243-527-3;methyl 2-methyl-3-(morpholin-4-yl)propanoate;SCHEMBL1816293;DTXSID50893282;Methyl 2-morpholinomethylpropanoate;MFCD00134816;Methyl2-methyl-3-morpholinopropanoate;AKOS008963301;2-Methyl-3-morpholinopropanoic acid methyl ester;4-Morpholinepropanoic acid, alpha-methyl-, methyl ester;4-Morpholinepropanoic acid, .alpha.-methyl-, methyl ester

Chemical Property of Methyl alpha-methyl-4-morpholinepropionate

Chemical Property:

• Vapor Pressure: 0.0113mmHg at 25°C
• Boiling Point: 261.8°Cat760mmHg
• Flash Point: 112.1°C
• PSA: 38.77000
• Density: 1.043g/cm³
• LogP: 0.06560
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 187.12084340
• Heavy Atom Count: 13
• Complexity: 166

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-methyl-3-morpholinopropanoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CN1CCOCC1)C(=O)OC

Technology Process of Methyl alpha-methyl-4-morpholinepropionate

There total 4 articles about Methyl alpha-methyl-4-morpholinepropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

morpholine (110-91-8,99108-56-2) + methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → (2-methyl-3-morpholin-4-yl)propionic acid methyl ester (20120-26-7)

Guidance literature:

With 1 mol% HClO4/SiO2; for 0.05h; Neat (no solvent); Microwave irradiation; Inert atmosphere;

DOI:10.1080/00397910902883579

Reference yield: 40.0%

morpholine (110-91-8,99108-56-2) + 3-Methyl-3-buten-2-one (814-78-8,25988-32-3) → (2-methyl-3-morpholin-4-yl)propionic acid methyl ester (20120-26-7) + 7-Methyl-hexahydro-pyrrolo[2,1-c][1,4]oxazin-6-one

Guidance literature:

With 9,10-phenanthrenequinone; In acetonitrile; at 5 ℃; for 2h; Irradiation;

Reference yield:

morpholine (110-91-8,99108-56-2) + methanol (67-56-1) + methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → (2-methyl-3-morpholin-4-yl)propionic acid methyl ester (20120-26-7)

Guidance literature:

at 40 - 50 ℃; for 124.5h;

upstream raw materials:

morpholine

methacrylic acid methyl ester

3-Methyl-3-buten-2-one

methanol

Downstream raw materials:

perfluoro(N-n-propylmorpholine)

perfluorodiethyl ether

2,2,3,3,5,5,6,6-Octafluoro-4-trifluoromethyl-morpholine

2-[difluoro-(2,2,3,3, 5,5,6,6-octafluoromorpholin-4-yl)methyl]-2,3,3,3-tetrafluoro-propanoyl fluoride

Refernces

• 1、 Singh, Surya Prakash,Kumar, T. Vijaya,Chandrasekharam,Giribabu,Reddy, P. Yella. "Microwave-assisted, rapid, solvent-free aza-michael reaction by perchloric acid impregnated on silica gel". . p. 3982 - 3989. Retrieved 2009.
• 2、 Steunenberg, Peter,Sijm, Maarten,Zuilhof, Han,Sanders, Johan P. M.,Scott, Elinor L.,Franssen, Maurice C. R.. "Lipase-catalyzed aza-michael reaction on acrylate derivatives". . p. 3802 - 3813. Retrieved 2013/06/05.