gamma-Glutamyl-glycyl-glycine

Base Information

• Chemical Name: gamma-Glutamyl-glycyl-glycine
• CAS No.: 13640-39-6
• Molecular Formula: C9H15 N3 O6
• Molecular Weight: 261.235
• Hs Code.: 2924199090
• NSC Number: 334202
• Mol file: 13640-39-6.mol

Synonyms:gamma-glutamyl-glycyl-glycine;Glu-Gly-Gly

Chemical Property of gamma-Glutamyl-glycyl-glycine

Chemical Property:

• Vapor Pressure: 1.5E-24mmHg at 25°C
• Boiling Point: 749°Cat760mmHg
• Flash Point: 406.8°C
• PSA: 158.82000
• Density: 1.433g/cm³
• LogP: -1.02240
• Storage Temp.: -15°C
• XLogP3: -4.8
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 8
• Exact Mass: 261.09608521
• Heavy Atom Count: 18
• Complexity: 343

Purity/Quality:

99% ^*data from raw suppliers

H-γ-Glu-Gly-Gly-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CC(=O)NCC(=O)NCC(=O)O)C(C(=O)O)N

Technology Process of gamma-Glutamyl-glycyl-glycine

There total 14 articles about gamma-Glutamyl-glycyl-glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

glycylglycine (556-50-3) + L-glutamic acid 5-(4-nitroanilide) (7300-59-6) → gamma-Glutamyl-glycyl-glycine (13640-39-6) + 4-nitro-aniline (100-01-6,104810-17-5)

Guidance literature:

With γ-glutamyltransferase from Bacillus subtilis; In aq. phosphate buffer; at 22 ℃; pH=8.5; pH-value; Enzymatic reaction;

DOI:10.1111/febs.12591

Reference yield:

GLUTATHIONE (70-18-8) + glycylglycine (556-50-3) → L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + gamma-Glutamyl-glycyl-glycine (13640-39-6)

Guidance literature:

With glutaminase from Pseudomonas nitroreducens IFO 12694; imidazole buffer; In water; at 30 ℃; for 1h; Product distribution; other reagent, pH dependence;

DOI:10.1271/bbb.62.1279

Reference yield:

L-glutamine (56-85-9,26700-71-0) + glycylglycine (556-50-3) → gamma-Glutamyl-glycyl-glycine (13640-39-6) + γ-glutamyl-γ-glutamylglycylglycine + γ-glutamyl-γ-glutamyl-γ-glutamylglycylglycine

Guidance literature:

With γ-glutamyltransferase from Bacillus subtilis; In aq. buffer; at 22 ℃; for 24h; pH=8.5; pH-value; Enzymatic reaction;

DOI:10.1111/febs.12591

upstream raw materials:

L-glutamine

glycylglycine

GLUTATHIONE

L-γ-glutamyl p-nitrophenyl ester

Downstream raw materials:

L-glutamic acid

glycylglycine

Refernces

• 1、 Morelli, Carlo F.,Calvio, Cinzia,Biagiotti, Marco,Speranza, Giovanna. "PH-Dependent hydrolase, glutaminase, transpeptidase and autotranspeptidase activities of Bacillus subtilis γ-glutamyltransferase". . p. 232 - 245. Retrieved 2014/01/23.
• 2、 Morin, Mylene,Rivard, Caroline,Keillor, Jeffrey W.. "γ-Glutamyl transpeptidase acylation with peptidic substrates: Free energy relationships measured by an HPLC kinetic assay". . p. 3790 - 3801. Retrieved 2008/09/18.