Norcepharadione B

Base Information

• Chemical Name: Norcepharadione B
• CAS No.: 57576-41-7
• Molecular Formula: C18H13NO4
• Molecular Weight: 307.30
• Mol file: 57576-41-7.mol

Synonyms:4H-Dibenzo[de,g]quinoline-4,5(6H)-dione,1,2- dimethoxy-;

Chemical Property of Norcepharadione B

Chemical Property:

• Refractive Index: 1.699
• PSA: 68.39000
• Density: 1.373 g/cm³
• LogP: 2.64970

Purity/Quality:

98%min ^*data from raw suppliers

NorcepharadioneB ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: This noraporphindione base occurs, with liriodenine and lysicamine, in the callus tissue of Stephania cephalantha. It forms reddish crystals from EtOH and has been separated from the accompanying bases by column chromatography

Technology Process of Norcepharadione B

There total 2 articles about Norcepharadione B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1,2,3,4-tetrahydro-1,6,7-trimethoxy-1-methylisoquinoline-3,4-dione (82359-80-6) + anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → norcepharadione B (57576-41-7)

Guidance literature:

With isopentyl nitrite; trichloroacetic acid; In 1,2-dimethoxyethane; Heating;

DOI:10.1021/jo00009a010

Reference yield:

6,7-Dimethoxy-1-methylene-1,2-dihydro-isoquinoline-3,4-dione (82359-79-3) + anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → norcepharadione B (57576-41-7)

Guidance literature:

With isopentyl nitrite; trichloroacetic acid; In 1,2-dimethoxyethane; for 7h; Heating;

DOI:10.1016/S0040-4039(00)86859-8

Reference yield: 65.0%

norcepharadione B (57576-41-7) + methyl trifluoromethanesulfonate (333-27-7) → cepharadione B (55610-02-1)

Guidance literature:

With sodium hydride; In 1,2-dimethoxyethane; for 2h;

DOI:10.1021/jo00009a010

upstream raw materials:

6,7-Dimethoxy-1-methylene-1,2-dihydro-isoquinoline-3,4-dione

anthranilic acid

1,2,3,4-tetrahydro-1,6,7-trimethoxy-1-methylisoquinoline-3,4-dione

Downstream raw materials:

cepharadione B

Refernces

• 1、 Castedo, Luis,Guitian, Enrique,Saa, Jose M.,Suau, Rafael. "NEW BENZYNE APPROACH TO THE SYNTHESIS OF DEHYDROAPORPHINES, 4,5-DIOXOAPORPHINES AND ARISTOLACTAMS". . p. 457 - 458. Retrieved 2007/10/02.