6-broMopyriMidin-4-aMine

Base Information

• Chemical Name: 6-broMopyriMidin-4-aMine
• CAS No.: 1159818-57-1
• Molecular Formula: C4H4BrN3
• Molecular Weight: 174
• Hs Code.: 2933599090
• Mol file: 1159818-57-1.mol

Synonyms:4-Bromo-6-aminopyrimidine;6-Bromopyrimidin-4-amine;4-Amino-6-bromopyrimidine;6-BROMO-PYRIMIDIN-4-YLAMINE;6-BROMO-4-AMINOPYRIMIDINE;6-BROMO-PYRIMIDINE-4-YLAMINE;查看更多英文别名收起

Chemical Property of 6-broMopyriMidin-4-aMine

Chemical Property:

• Boiling Point: 303.2 °C at 760 mmHg
• PKA: 2.16±0.10(Predicted)
• Flash Point: 137.2 °C
• PSA: 51.80000
• Density: 1.844 g/cm³
• LogP: 1.40250
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Amino-6-bromopyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-broMopyriMidin-4-aMine

There total 1 articles about 6-broMopyriMidin-4-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,6-dibromopyrimidine (36847-10-6) → 4-amino-6-bromopyrimidine (1159818-57-1)

Guidance literature:

With ammonium hydroxide; In acetonitrile; at 20 ℃; for 16h;

Reference yield: 81.0%

4-amino-6-bromopyrimidine (1159818-57-1) + C39H55BN2O6Si → C26H25N5O2

Guidance literature:

With palladium diacetate; potassium carbonate; tricyclohexylphosphine; In 1,2-dimethoxyethane; water; at 100 ℃; for 4h;

Reference yield: 77.0%

1-(4-methylbenzenesulfonyl)-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine (866545-91-7) + 4-amino-6-bromopyrimidine (1159818-57-1) → 6-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-amine

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,2-dimethoxyethane; water; at 120 ℃; for 3h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.bmcl.2020.127721

upstream raw materials:

4,6-dibromopyrimidine

Downstream raw materials:

(S)-6-(2-(3-Phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyrrolidin-1-yl)pyrimidin-4-amine

(S)-N₄-(1-(3-Phenyl-3H-imidazo[4,5-b]pyridin-2-yl)ethyl)pyrimidine-4,6-diamine

2-((6-aminopyrimidin-4-ylamino)methyl)-5-chloro-3-o-tolylpyrrolo[1,2-f][1,2,4]triazin-4(3H)-one

2-((6-aminopyrimidin-4-ylamino)methyl)-3-o-tolylpyrrolo[1,2-f][1,2,4]triazin-4(3H)-one

Refernces

• 1、 -. "PESTICIDALLY ACTIVE POLYCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS". Page/Page column 84. . Retrieved 2016/06/01.