Epinastine hydrochloride

Base Information

• Chemical Name: Epinastine hydrochloride
• CAS No.: 108929-04-0
• Deprecated CAS: 80012-44-8
• Molecular Formula: C16H15N3^.HCl
• Molecular Weight: 285.776
• Hs Code.: 2933992600
• European Community (EC) Number: 629-843-8
• UNII: GFM415S5XL
• DSSTox Substance ID: DTXSID1046502
• Wikidata: Q27122286
• NCI Thesaurus Code: C47512
• RXCUI: 236961
• ChEMBL ID: CHEMBL1200491
• Mol file: 108929-04-0.mol

Synonyms:3-amino-9,13b-dihydro-1H-benz(c,f)imidazo(1,5a)azepine;epinastine;epinastine hydrochloride;Flurinol;WAL 80;WAL 801;WAL 801 CL;WAL 801CL;WAL-80 Cl

Chemical Property of Epinastine hydrochloride

Chemical Property:

• Appearance/Colour: White crystalline solid
• Vapor Pressure: 1.56E-07mmHg at 25°C
• Melting Point: 273-275 °C
• Boiling Point: 428 °C at 760 mmHg
• Flash Point: 212.7 °C
• PSA: 41.62000
• Density: 1.32g/cm3
• LogP: 3.46970
• Storage Temp.: 2-8°C
• Solubility.: H2O: soluble38mg/mL
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 285.1032752
• Heavy Atom Count: 20
• Complexity: 378

Purity/Quality:

99% ^*data from raw suppliers

Epinastine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2C3=CC=CC=C3CC4=CC=CC=C4N2C(=N1)N.Cl
• Recent ClinicalTrials: Study of Two Marketed Ocular Anti-Allergy Medications in Subjects With Allergic Conjunctivitis
• Recent NIPH Clinical Trials: Efficacy of the combination treatment of epinastine hydrochloride 0.1% and bromfenac sodium ophthalmic solution for allergic conjunctivitis.
• Uses: A tetracyclic, non-sedating histamine H1 receptor antagonist. Antihistaminic.

Technology Process of Epinastine hydrochloride

There total 19 articles about Epinastine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

epinastine (80012-43-7) → epinastine hydrochloride (108929-04-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; ethyl acetate; for 0.5h; Product distribution / selectivity;

Reference yield: 87.0%

9H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine (706753-75-5) → epinastine hydrochloride (108929-04-0)

Guidance literature:

With hydrogenchloride; palladium on activated carbon; hydrogen; In ethanol; water; for 24h;

DOI:10.1016/j.tetlet.2019.151451

Reference yield:

bromocyane (506-68-3) + 6-aminomethyl-6,11-dihydro-5H-dibenzo[b,e]azepine (41218-84-2) → epinastine hydrochloride (108929-04-0)

Guidance literature:

With hydrogenchloride; In water;

upstream raw materials:

3-amino-9,13b-dihydro-1H-dibenzimidazo<1,5-a>azepine hydrobromide

6-chloro-11H-dibenzazepine

11H-dibenzazepine-6-carbonitrile

6-aminomethyl-6,11-dihydro-5H-dibenzo[b,e]azepine

Refernces

• 1、 -. "Novel method of preparing Epinastine". . . Retrieved 2020/05/13.
• 2、 -. "Synthesis method of epinastine hydrochloride". Paragraph 0027; 0030-0031; 0035-0036; 0040-0041; 0045-0046. . Retrieved 2018/09/08.