BIS-(4-N,N-DIMETHYLAMINOPHENYL) PHENYLACTONITRILE

Base Information

• Chemical Name: BIS-(4-N,N-DIMETHYLAMINOPHENYL) PHENYLACTONITRILE
• CAS No.: 4468-56-8
• Molecular Formula: C24H25 N3
• Molecular Weight: 355.483
• Mol file: 4468-56-8.mol

Synonyms:Acetonitrile,bis[p-(dimethylamino)phenyl]phenyl- (6CI,7CI,8CI); Malachite green cyanide;Malachite green leucocyanide; Malachite green leuconitrile; NSC 3509

Chemical Property of BIS-(4-N,N-DIMETHYLAMINOPHENYL) PHENYLACTONITRILE

Chemical Property:

• Vapor Pressure: 2.15E-10mmHg at 25°C
• Boiling Point: 506.8°Cat760mmHg
• Flash Point: 212.5°C
• PSA: 30.27000
• Density: 1.115g/cm³
• LogP: 4.67658

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BIS-(4-N,N-DIMETHYLAMINOPHENYL) PHENYLACTONITRILE

There total 10 articles about BIS-(4-N,N-DIMETHYLAMINOPHENYL) PHENYLACTONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

potassium cyanide (151-50-8) + malachite green oxalate (13425-25-7,49722-68-1) → bis(4-N,N-dimethylaminophenyl)phenylacetonitrile (4468-56-8)

Guidance literature:

With hydrogenchloride; In water;

DOI:10.1021/jo000374a

Reference yield: 72.0%

1-phenyl-1H-indole (16096-33-6) + 2-diazo-2-phenylacetonitrile (61766-63-0) + N,N-dimethyl-aniline (121-69-7,77733-26-7) → bis(4-N,N-dimethylaminophenyl)phenylacetonitrile (4468-56-8) + 2-(4-(dimethylamino)phenyl)-2-phenyl-2-(1-phenyl-1H-indol-3-yl)acetonitrile

Guidance literature:

With diphenyl hydrogen phosphate; (triphenyl phosphite)gold(I) chloride; silver trifluoromethanesulfonate; In tetrahydrofuran; at 25 ℃; for 6h; Reagent/catalyst; Solvent; Catalytic behavior; Inert atmosphere;

DOI:10.1002/adsc.202000879

Reference yield: 63.0%

2-diazo-2-phenylacetonitrile (61766-63-0) + N,N-bis(2-methoxyethyl)-benzenamide (87182-67-0) + N,N-dimethyl-aniline (121-69-7,77733-26-7) → bis(4-N,N-dimethylaminophenyl)phenylacetonitrile (4468-56-8) + 2-(4-(bis(2-methoxyethyl)amino)phenyl)-2-(4-(dimethylamino)phenyl)-2-phenylacetonitrile

Guidance literature:

With diphenyl hydrogen phosphate; (triphenyl phosphite)gold(I) chloride; silver trifluoromethanesulfonate; In tetrahydrofuran; at 25 ℃; Inert atmosphere;

DOI:10.1002/adsc.202000879

upstream raw materials:

malachit green

potassium cyanide

cyanide^(1-)

malachite green oxalate

Downstream raw materials:

1,1-bis(4-dimethylaminophenyl)-1-phenyl-2-propanone oxime

α,α-bis(4-dimethylaminophenyl)phenylacetic acid

malachit green

radical of leucobase of Malachite Green

Refernces

• 1、 -. "COMPOSITIONS AND METHODS FOR DETECTING NERVE AGENTS". Page/Page column 33. . Retrieved 2010/06/14.
• 2、 Sinev, V. V.,Nikolova, T. A.. "EFFECT OF STRUCTURAL FACTORS ON THE KINETICS OF THE REACTION OF THE CONJUGATE IONS OF THE TRIARYLMETHANE SERIES WITH THE CYANIDE ION". . p. 707 - 713. Retrieved 2007/10/02.