3,3'-Diamino-4,4'-dihydroxydiphenyl Sulfone

Base Information

• Chemical Name: 3,3'-Diamino-4,4'-dihydroxydiphenyl Sulfone
• CAS No.: 7545-50-8
• Molecular Formula: C12H12N2O4S
• Molecular Weight: 280.304
• Hs Code.: 29222990
• European Community (EC) Number: 231-428-8
• NSC Number: 155173
• DSSTox Substance ID: DTXSID40226383
• Nikkaji Number: J307.872H
• Wikidata: Q72462821
• ChEMBL ID: CHEMBL1566370
• Mol file: 7545-50-8.mol

Synonyms:7545-50-8;3,3'-Diamino-4,4'-dihydroxydiphenyl Sulfone;4,4'-Sulfonylbis(2-aminophenol);Bis(3-amino-4-hydroxyphenyl) Sulfone;Bis(3-amino-4-hydroxyphenyl)sulfone;Phenol, 4,4'-sulfonylbis[2-amino-;2-amino-4-[(3-amino-4-hydroxyphenyl)sulfonyl]phenol;4,4'-Sulphonylbis(2-aminophenol);4,4'-sulphonylbis[2-aminophenol];NSC155173;2-amino-4-(3-amino-4-hydroxyphenyl)sulfonylphenol;3-amino-4-hydroxyphenyl sulfone;EINECS 231-428-8;2-AMINO-4-[(3-AMINO-4-HYDROXYPHENYL)-SULFONYL]PHENOL;Phenol, 4,4'-sulfonylbis(2-amino-;Cambridge id 5105145;Oprea1_144507;Oprea1_606502;CBDivE_002025;MLS000673851;SCHEMBL109925;2-amino-4-(3-amino-4-hydroxybenzenesulfonyl)phenol;CHEMBL1566370;DTXSID40226383;HMS2774C03;3-Amino-?4-?hydroxyphenyl Sulfone;MFCD00025181;STK025810;2,2'-Diamino-4,4'-sulfonyldiphenol;AKOS000266219;CS-W014015;NSC 155173;NSC-155173;NCGC00245961-01;DS-15330;SMR000315092;3,3'-diamino-4,4'-dihydroxydiphenylsulfone;B2859;EU-0099868;H10866;A838419;2-amino-4-(3-amino-4-hydroxy-phenyl)sulfonyl-phenol;7-[2-[[(3-chlorophenyl)-phenyl-methyl]amino]ethyl]-1,3-dimethyl-purine-2,6-dione;3,3'-Diamino-4,4'-dihydroxydiphenyl sulfone

Chemical Property of 3,3'-Diamino-4,4'-dihydroxydiphenyl Sulfone

Chemical Property:

• Appearance/Colour: Baby pink powder
• Melting Point: 231 °C
• Boiling Point: 596.9 °C at 760 mmHg
• PKA: 6.62±0.20(Predicted)
• Flash Point: 314.8 °C
• PSA: 135.02000
• Density: 1.564 g/cm³
• LogP: 3.33820
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: slightly sol. in Methanol
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 280.05177804
• Heavy Atom Count: 19
• Complexity: 376

Purity/Quality:

98%, ^*data from raw suppliers

3,3''-Diamino-4,4''-dihydroxydiphenylSulfone ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=C(C=C1S(=O)(=O)C2=CC(=C(C=C2)O)N)N)O

Technology Process of 3,3'-Diamino-4,4'-dihydroxydiphenyl Sulfone

There total 10 articles about 3,3'-Diamino-4,4'-dihydroxydiphenyl Sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,3'-dibromo-4,4'-dihydroxydiphenyl sulfone (56486-79-4) → 3,3'-diamino-4,4'-dihydroxydiphenyl sulfone (7545-50-8)

Guidance literature:

With ammonium hydroxide; In 1-methyl-pyrrolidin-2-one; at 150 ℃; Solvent; Temperature;

Reference yield: 94.0%

3,3'-dinitro-4,4'-dihydroxydiphenylsulfone (7149-20-4) → 3,3'-diamino-4,4'-dihydroxydiphenyl sulfone (7545-50-8)

Guidance literature:

With palladium 10% on activated carbon; hydrazine hydrate; In 1,4-dioxane; ethanol; at 95 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c4cc05964f

Reference yield:

4,4'-dibromodiphenyl sulfone (2050-48-8) → 3,3'-diamino-4,4'-dihydroxydiphenyl sulfone (7545-50-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; potassium nitrate / 3 h / 80 °C

2: sodium hydroxide / dimethyl sulfoxide; water / 2 h / 50 °C

3: palladium 10% on activated carbon; hydrazine hydrate / ethanol; 1,4-dioxane / 24 h / 95 °C / Inert atmosphere

With sulfuric acid; palladium 10% on activated carbon; hydrazine hydrate; potassium nitrate; sodium hydroxide; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide;

DOI:10.1039/c4cc05964f

upstream raw materials:

3,3'-dinitro-4,4'-dihydroxydiphenylsulfone

4,4'-sulfonediphenol

bis[3-methyl-4-hydroxyphenyl]sulfone

ortho-cresol

Refernces

• 1、 -. "Preparation method of 3,3'-diamino-4,4'dyhydroxy diphenyl sulfone". Paragraph 0005; 0030; 0031; 0032. . Retrieved 2017/01/17.
• 2、 -. "Bisfluoran chromogenic compounds, preparation thereof, and pressure-sensitive copy systems employing same". . . Retrieved 2008/06/13.