Fomivirsen

Base Information

• Chemical Name: Fomivirsen
• CAS No.: 144245-52-3
• Molecular Formula: C204H263 N63 O114 P20 S20
• Molecular Weight: 6682.45
• Mol file: 144245-52-3.mol

Synonyms:Deoxyribonucleicacid, d(P-thio)(G-C-G-T-T-T-G-C-T-C-T-T-C-T-T-C-T-T-G-C-G); Fomivirsen; ISIS 2922

Chemical Property of Fomivirsen

Chemical Property:

• PSA: 3279.10000
• LogP: 15.76190

Purity/Quality:

98%Min ^*data from raw suppliers

FOMIVIRSEN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Fomivirsen sodium (Vitravenes, Isis Pharmaceuticals, Carlsbad, CA, and Novartis Pharmaceuticals, Switzerland), is a 21-base phosphorothioate DNA antisense oligonucleotide designed to be complimentary to a cytomegalovirus (CMV) messenger RNA (mRNA) which encodes for the major immediate early region (IE2) proteins of this virus. It is the first in its class of highly specific and novel therapeutics, antisense oligonucleotides. The sequence of the fomivirsen oligonucleotide is 5u-GCG TTT GCT CTT CTT CTT GCG-3u (where G = guanosine, C = cytosine, T = thymidine). Fomivirsen sodium intravitreal injectable (fomivirsen) is a white to off-white, hygroscopic, amorphous powder. Fomivirsen is available as a sterile, aqueous, preservative-free and bicarbonate-buffered solution.
• Indications: Fomivirsen (Vitravene), an anti-CMV agent, is the first antisense oligonucleotide to be approved by the U. S. Food and Drug Administration (FDA) as an antiviral therapy. Fomivirsen is an oligonucleotide complementary to the major immediate early region 2 (IE2) of CMV mRNA. By binding to IE2 mRNA, fomivirsen prevents its translation to protein and thereby blocks viral replication. Because this mechanism of action is different from that of other antiviral agents, crossresistance with other drugs used to treat CMV is unlikely.
• Clinical Use: CMV retinitis in AIDS patients intolerant of, or unresponsive to, other treatments Fomivirsen is used to treat CMV retinitis in patients with AIDS who have not responded to other treatments or in whom other treatments are contraindicated. It appears to be at least as effective as other treatments and produces fewer side effects. Because CMV retinitis is often associated with CMV infection elsewhere in the body, patients undergoing treatment with fomivirsen should be monitored for extraocular CMV disease.