2,2',4-Trihydroxy-4'-methoxybenzophenone

Base Information

• Chemical Name: 2,2',4-Trihydroxy-4'-methoxybenzophenone
• CAS No.: 7392-62-3
• Molecular Formula: C14H12O5
• Molecular Weight: 260.246
• Hs Code.: 2914509090
• European Community (EC) Number: 230-984-9
• DSSTox Substance ID: DTXSID7064657
• Nikkaji Number: J278.806C
• Wikidata: Q81991745
• Mol file: 7392-62-3.mol

Synonyms:2,2',4-Trihydroxy-4'-methoxybenzophenone;7392-62-3;EINECS 230-984-9;Methanone, (2,4-dihydroxyphenyl)(2-hydroxy-4-methoxyphenyl)-;SCHEMBL93206;DTXSID7064657;2,2',4'-Trihydroxy-4-methoxybenzophenone;2,4-Dihydroxyphenyl(2-hydroxy-4-methoxyphenyl) ketone

Chemical Property of 2,2',4-Trihydroxy-4'-methoxybenzophenone

Chemical Property:

• Melting Point: 101-102°C
• Boiling Point: 478.5°Cat760mmHg
• Flash Point: 184.9°C
• PSA: 86.99000
• Density: 1.392g/cm³
• LogP: 2.04300
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 260.06847348
• Heavy Atom Count: 19
• Complexity: 319

Purity/Quality:

99% ^*data from raw suppliers

(2,4-DIHYDROXYPHENYL)-(2-HYDROXY-4-METHOXYPHENYL)METHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)C(=O)C2=C(C=C(C=C2)O)O)O

Technology Process of 2,2',4-Trihydroxy-4'-methoxybenzophenone

There total 6 articles about 2,2',4-Trihydroxy-4'-methoxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2',4,4'-tetrahydroxybenzophenone (131-55-5) + methyl iodide (74-88-4) → (2,4-dihydroxyphenyl)(2-hydroxy-4-methoxyphenyl)methanone (7392-62-3)

Guidance literature:

With caesium carbonate; In butanone; at 20 ℃; for 48h;

Reference yield:

(2-hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)-methanone (131-53-3) → 2,2',4-Trihydroxybenzophenone (13087-18-8) + (2,4-dihydroxyphenyl)(2-hydroxy-4-methoxyphenyl)methanone (7392-62-3)

Guidance literature:

With water; NADPH; In aq. phosphate buffer; at 37 ℃; for 2.5h; pH=7.4; Microbiological reaction;

DOI:10.1016/j.envpol.2020.115766

Reference yield:

bis(2-hydroxy-4-methoxyphenyl)-methanone (131-54-4) → (2,4-dihydroxyphenyl)(2-hydroxy-4-methoxyphenyl)methanone (7392-62-3)

Guidance literature:

With boron tribromide; In dichloromethane; for 48h; Inert atmosphere;

DOI:10.1016/j.envpol.2020.115766

upstream raw materials:

O-methylresorcine

4-hydroxysalicylic acid

1,3-Dimethoxybenzene

2,2',4,4'-tetrahydroxybenzophenone

Downstream raw materials:

4-(4-methoxy-2-propyloxyphenyl)-3-phenyl-7-propyloxycoumarin

7-methoxy-3-phenyl-4-(2,4-dipropyloxyphenyl)coumarin

Refernces

• 1、 -. "ULTRAVIOLET LIGHT ABSORBERS". Paragraph 0256. . Retrieved 2017/10/10.