Ciprofloxacin Hydrochloride

Base Information

• Chemical Name: Ciprofloxacin Hydrochloride
• CAS No.: 86483-48-9
• Molecular Formula: C₁₇H₁₈FN₃O₃*ClH
• Molecular Weight: 367.808
• Hs Code.: 29419000
• European Community (EC) Number: 642-985-5,658-041-0,849-041-3
• NSC Number: 620634
• UNII: 0MP32MFP6C
• DSSTox Substance ID: DTXSID1047788
• Wikidata: Q27105154
• NCI Thesaurus Code: C47976
• RXCUI: 81981
• ChEMBL ID: CHEMBL1202
• Mol file: 86483-48-9.mol

Synonyms:Anhydrous, Ciprofloxacin Hydrochloride;Bay 09867;Bay-09867;Bay09867;Ciprinol;Cipro;Ciprofloxacin;Ciprofloxacin Hydrochloride;Ciprofloxacin Hydrochloride Anhydrous;Ciprofloxacin Monohydrochloride Monohydrate;Hydrochloride Anhydrous, Ciprofloxacin;Hydrochloride, Ciprofloxacin;Monohydrate, Ciprofloxacin Monohydrochloride;Monohydrochloride Monohydrate, Ciprofloxacin

Chemical Property of Ciprofloxacin Hydrochloride

Chemical Property:

• Appearance/Colour: white or light yellow crystalline powder
• Melting Point: >300 °C
• Boiling Point: 581.8 °C at 760 mmHg
• Flash Point: 305.6 °C
• PSA: 74.57000
• LogP: 2.77910
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO (Slightly, Heated), Methanol (Slightly, Heated)
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 367.1098973
• Heavy Atom Count: 25
• Complexity: 571

Purity/Quality:

99%, ^*data from raw suppliers

Ciprofloxacin Hydrochloride, Monohydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O.Cl
• Recent ClinicalTrials: Bioequivalence Study of Ciprofloxacin in Healthy Adult Subjects Under Fasting Condition
• Recent EU Clinical Trials: ABSORB 2:An exploratie study determining the oral antibiotic drug absorption in patients with short bowel syndrome.
• Uses: Ciprofloxacin hydrochloride, C17H18FN3O3 ?HCl?H2O, is a synthetic broad-spectrum antibacterial agent. Ciprofloxacin differs from other quinolones in that it has a fluorine atom at the 6-position, a piperazine moiety at the 7-position, and a cyclopropyl ring at the 1-position. it was the drug of choice forcombating anthrax. Ciprofloxacin hydrochloride (Cipro, 500-mg tablets) is highly active against the important bacterial causes of enteritis, including diarrheogenic Escherichia coli, Vibrio cholerae, Salmonella species, Shigella species, Campylobacter jejuni, Aeromonas species, and Yersinia enterocolitica. Ciprofloxacin Hydrochloride Monohydrate is a fluorinated quinolone antibacterial.

Technology Process of Ciprofloxacin Hydrochloride

There total 2 articles about Ciprofloxacin Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

piperazine (110-85-0) + 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid (86393-33-1,178489-04-8) → 7-chloro-1-cyclopropyl-4-oxo-6-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid; hydrochloride (526204-10-4) + ciprofloxacin hydrochloride (93107-08-5,86483-48-9)

Guidance literature:

piperazine; 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid; for 0.333333h; microwave irradiation;

With hydrogenchloride; In water; pH=7;

DOI:10.1515/HC.2005.11.5.423

Reference yield:

piperazine (110-85-0) + 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid (86393-33-1,178489-04-8) + dimethyl sulfoxide (67-68-5,8070-53-9) → ciprofloxacin (85721-33-1,178489-05-9,189257-90-7) + ciprofloxacin hydrochloride (93107-08-5,86483-48-9)

Guidance literature:

In water;

Reference yield: 100.0%

ciprofloxacin hydrochloride (93107-08-5,86483-48-9) + benzoyl chloride (98-88-4) → N-benzoylciprofloxacin

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 0 - 20 ℃; for 2h;

DOI:10.1007/s11095-013-1250-x

upstream raw materials:

piperazine

7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid

dimethyl sulfoxide

Downstream raw materials:

1-cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

enrofloxacin

Refernces

• 1、 -. "6-fluoro-7-chloro-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid". . . Retrieved 2008/06/13.