Ethylphosphonic acid

Base Information

• Chemical Name: Ethylphosphonic acid
• CAS No.: 6779-09-5
• Molecular Formula: C2H7 O3 P
• Molecular Weight: 110.05
• Hs Code.: 2931900090
• European Community (EC) Number: 229-839-2
• UNII: SEL78D6NLX
• DSSTox Substance ID: DTXSID20218044
• Nikkaji Number: J135.779D
• Wikidata: Q69756364
• ChEMBL ID: CHEMBL3234431
• Mol file: 6779-09-5.mol

Synonyms:Ethylphosphonic acid;6779-09-5;Ethanephosphonic acid;4-Ethylphosphonic Acid;Phosphonic acid, ethyl-;SEL78D6NLX;ETHYLPHOSPHONATE;UNII-SEL78D6NLX;Ethylphosphonic acid, 98%;SCHEMBL35435;P-ETHYLPHOSPHONIC ACID;SCHEMBL9711348;CHEMBL3234431;BDBM84557;DTXSID20218044;CHEBI:139369;PHOSPHONIC ACID, P-ETHYL-;EINECS 229-839-2;MFCD00002141;AKOS015892851;FT-0695008

Chemical Property of Ethylphosphonic acid

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 0.00365mmHg at 25°C
• Melting Point: 61-63 °C(lit.)
• Boiling Point: 330-340℃ (8 Torr)
• PKA: pK1:2.43;pK2:8.05 (25°C)
• Flash Point: 111.3°C
• PSA: 67.34000
• LogP: 0.18400
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Sensitive.: Moisture Sensitive
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: Soluble in water.
• XLogP3: -1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 110.01328108
• Heavy Atom Count: 6
• Complexity: 72.9

Purity/Quality:

99% ^*data from raw suppliers

4-EthylphosphonicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R34:Causes burns.
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-28-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCP(=O)(O)O
• Uses: Ethylphosphonic acid is used as an internal standard in the determination of fosfomycin in human plasma. It is also used in the synthesis of nucleotide analogs.

Technology Process of Ethylphosphonic acid

There total 22 articles about Ethylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethylphosphinic acid (4363-06-8) → ethylphosphonic acid (6779-09-5)

Guidance literature:

With 5 % platinum on carbon; oxygen; sodium hydroxide; In water; at 70 ℃; pH=9;

Reference yield:

ethene (74-85-1) → ethylphosphonic acid (6779-09-5) + diethylphosphinic acid (813-76-3)

Guidance literature:

ethene; With sodium hypophosphite monohydrate; In water; at 100 ℃; Large scale;

With nitric acid; In water; Overall yield = 92 %; Large scale;

Reference yield:

ethylphosphonic acid diethyl ester (78-38-6) → ethylphosphonic acid (6779-09-5)

Guidance literature:

With hydrogenchloride; at 150 ℃;

upstream raw materials:

ethyl bromide

ethyl phosphine

ethylphosphinic acid

ethylphosphonic acid diethyl ester

Downstream raw materials:

Ethylphosphonic dichloride

ethane

ethene

ethylphosphonic acid diethyl ester

Refernces

• 1、 -. "Method for the production of alkylphosphonic acids, esters, and salts by oxidizing alkylphosphonous acids, and use thereof". Page/Page column 24. . Retrieved 2015/05/05.
• 2、 -. "Process for the production of aliphatic phosphonic acids". . . Retrieved 2008/06/13.