2-methylpropyl hydroxy(phenyl)acetate

Base Information

• Chemical Name: 2-methylpropyl hydroxy(phenyl)acetate
• CAS No.: 29664-59-3
• Molecular Formula: C12H16 O3
• Molecular Weight: 208.257
• Mol file: 29664-59-3.mol

Synonyms:Mandelicacid, isobutyl ester (8CI); Isobutyl 2-hydroxy-2-phenylacetate; Isobutylmandelate; NSC 13533

Chemical Property of 2-methylpropyl hydroxy(phenyl)acetate

Chemical Property:

• Vapor Pressure: 0.000308mmHg at 25°C
• Boiling Point: 307.8°Cat760mmHg
• Flash Point: 124.7°C
• Density: 1.093g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methylpropyl hydroxy(phenyl)acetate

There total 5 articles about 2-methylpropyl hydroxy(phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-methyl-propan-1-ol (78-83-1) + MANDELIC ACID (611-71-2,611-72-3,17199-29-0,90-64-2) → α-hydroxyphenylacetic acid iso-butyl ester (29664-59-3)

Guidance literature:

With 4-(dihydroxyboranyl)-1-methylpyridin-1-ium iodide; for 6h; Heating;

DOI:10.1021/ol052061d DOI:10.1016/j.tet.2007.03.157

Reference yield: 87.0%

isobutyl α-phenyl-α-diazoacetate → α-hydroxyphenylacetic acid iso-butyl ester (29664-59-3)

Guidance literature:

With rhodium (II) octanoate dimer; water; In dichloromethane;

DOI:10.1002/chem.201101590

Reference yield: 85.0%

iso-butyl 2-oxo-2-phenylacetate (31197-67-8) → α-hydroxyphenylacetic acid iso-butyl ester (29664-59-3)

Guidance literature:

With methanol; benzaldehyde; 1,3-bis(mesityl)imidazolium chloride; triethylamine; at 25 ℃; for 5h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.12.022

upstream raw materials:

2-methyl-propan-1-ol

MANDELIC ACID

iso-butyl 2-oxo-2-phenylacetate

(Z)-isobutyl 2-phenyl-2-(2-tosylhydrazono)acetate

Downstream raw materials:

iso-butyl 2-oxo-2-phenylacetate

(S)-α-hydroxyphenylacetic acid iso-butyl ester

(R)-α-hydroxyphenylacetic acid iso-butyl ester

Refernces

• 1、 Sreenivasulu,Arun Kumar,Sateesh Reddy,Siva Kumar,Rajender Kumar,Chandrasekhar,Pal, Manojit. "1,3-Bis(2,4,6-trimethylphenyl)imidazolium chloride in combination with triethylamine: An improved catalytic system for hydroacylation/reduction of activated ketones". supporting information; experimental part. p. 727 - 732. Retrieved 2011/03/21.
• 2、 Maki, Toshikatsu,Ishihara, Kazuaki,Yamamoto, Hisashi. "New boron(III)-catalyzed amide and ester condensation reactions". . p. 8645 - 8657. Retrieved 2008/02/08.