tert-butyl (4-nitrophenyl)acetate

Base Information

• Chemical Name: tert-butyl (4-nitrophenyl)acetate
• CAS No.: 29704-38-9
• Molecular Formula: C12H15 N O4
• Molecular Weight: 237.255
• Mol file: 29704-38-9.mol

Synonyms:Aceticacid, (p-nitrophenyl)-, tert-butyl ester (8CI); (4-Nitrophenyl)acetic acidtert-butyl ester; 2-(4-Nitrophenyl)acetic acid tert-butyl ester; NSC 408625

Chemical Property of tert-butyl (4-nitrophenyl)acetate

Chemical Property:

• Vapor Pressure: 0.000104mmHg at 25°C
• Boiling Point: 337.5°Cat760mmHg
• Flash Point: 137.6°C
• Density: 1.164g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl (4-nitrophenyl)acetate

There total 16 articles about tert-butyl (4-nitrophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butoxycarbonylmethylzinc bromide tetrahydrofuran salt + para-nitrophenyl bromide (586-78-7) → (4-nitrophenyl)acetic acid tert-butyl ester (29704-38-9)

Guidance literature:

With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere; Sealed tube;

DOI:10.1021/jo401476f

Reference yield: 95.0%

4-nitrobenzeneacetic acid (104-03-0) + tert-butyl alcohol (75-65-0) → (4-nitrophenyl)acetic acid tert-butyl ester (29704-38-9)

Guidance literature:

With pyridine; trichlorophosphate; In chloroform; for 5h;

DOI:10.1021/ja200808y

Reference yield: 92.0%

acetic acid tert-butyl ester (540-88-5) + para-nitrophenyl bromide (586-78-7) → (4-nitrophenyl)acetic acid tert-butyl ester (29704-38-9)

Guidance literature:

acetic acid tert-butyl ester; With lithium hexamethyldisilazane; In toluene; at -78 ℃; for 1h; Inert atmosphere; Sealed tube;

With zinc(II) chloride; In tetrahydrofuran; toluene; at -78 ℃; for 0.5h; Inert atmosphere; Sealed tube;

para-nitrophenyl bromide; With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; toluene; at 20 ℃; for 4h; Inert atmosphere; Sealed tube;

DOI:10.1021/jo401476f

upstream raw materials:

tert-butyl alcohol

4-nitrophenylacetyl chloride

para-dinitrobenzene

acetic acid tert-butyl ester

Downstream raw materials:

(4-aminophenyl)acetic acid tert-butyl ester

tert-butyl 2-bromo-2-(4-nitrophenyl)acetate

9-(4((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-tert-butoxy-4-oxobutanamido)phenyl)-1-(4-((E)-(4-(dimethylamino)phenyl)diazenyl)phenyl)-1,7,10-trioxo-8-oxa-2,6,11-triazatridecan-13-oic acid

(E)-9-(4-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-4-tert-butoxy-4-oxobutanamido)phenyl)-1-(4-((4-(dimethylamino)phenyl)diazenyl)phenyl)-1,7,10-trioxo-8-oxa-2,6,11-triazatridecan-13-oic acid

Refernces

• 1、 -. "Pyridazine-3-carboxamide compound and preparation method and application thereof in medicine". Paragraph 0700-0706. . Retrieved 2020/03/02.
• 2、 Zhang, Ningning,Yang, Rui,Zhang-Negrerie, Daisy,Du, Yunfei,Zhao, Kang. "Direct conversion of N -alkoxyamides to carboxylic esters through tandem nbs-mediated oxidative homocoupling and thermal denitrogenation". . p. 8705 - 8711. Retrieved 2013/09/24.