1-Amino-2,4-dibromonaphthalene

Base Information

• Chemical Name: 1-Amino-2,4-dibromonaphthalene
• CAS No.: 20191-76-8
• Molecular Formula: C10H7Br2N
• Molecular Weight: 300.98
• Hs Code.: 2921450090
• Mol file: 20191-76-8.mol

Synonyms:1-Naphthalenamine, 2,4-dibromo-;2.4-Dibrom-1-amino-naphthalin;2,4-dibromo-naphthalen-1-ylamine;2,4-dibromo-1-naphthalenamine;1-Amino-2,4-dibromonaphthalene;2,4-dibromo-1-naphthylamine;

Chemical Property of 1-Amino-2,4-dibromonaphthalene

Chemical Property:

• Vapor Pressure: 1.16E-05mmHg at 25°C
• Melting Point: 115 °C
• Boiling Point: 369.7°C at 760 mmHg
• PKA: -0.22±0.10(Predicted)
• Flash Point: 177.4°C
• PSA: 26.02000
• Density: 1.902g/cm³
• LogP: 4.52820
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Dibromonaphthalen-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2,4-Dibromonaphthalen-1-amine is used as a reactant in the preparation of pyrazoles as inhibitors of macrophage migration inhibitory factor.

Technology Process of 1-Amino-2,4-dibromonaphthalene

There total 13 articles about 1-Amino-2,4-dibromonaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-amino-naphthalene (134-32-7) → 2,4-dibromo-1-naphthylamine (20191-76-8)

Guidance literature:

With N-Bromosuccinimide; lithium perchlorate; silica gel; In dichloromethane; at 20 ℃; for 0.0833333h;

DOI:10.1139/v05-001

Reference yield: 42.0%

1-amino-naphthalene (134-32-7) → 4-Bromo-1-naphthylamine (2298-07-9) + 2,4-dibromo-1-naphthylamine (20191-76-8)

Guidance literature:

1-amino-naphthalene; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 1h;

With poly[4-(dibutyliodostannyl)butyl]styrene; In diethyl ether; hexane; at 20 ℃; for 18h;

With bromine; In diethyl ether; hexane; dichloromethane; at -78 - 20 ℃; for 2h;

DOI:10.1021/jo0480141

Reference yield:

1-amino-5,8-dihydronaphthalene (32666-56-1) → 2,4-dibromo-1-naphthylamine (20191-76-8)

Guidance literature:

With chloroform; bromine; at 0 ℃;

upstream raw materials:

4-amino-1-naphthalenesufonic acid

1-amino-5,8-dihydronaphthalene

N-benzylidenenaphthalen-1-amine

N-(2,4-dibromo-[1]naphthyl)-acetamide

Downstream raw materials:

3-nitro-benzenesulfonic acid-(2,4-dibromo-[1]naphthylamide)

1-amino-naphthalene

4-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)naphthalen-2-ol

ethyl 3-(3-methoxy-1-naphthylamino)benzoate

Refernces

• 1、 Ruggli,Braun. "-". . p. 858,863. Retrieved 1933.
• 2、 -. "KRAS G12C INHIBITORS". Paragraph 0253; 0278. . Retrieved 2020/03/23.
• 3、 -. "Anthracene derivatives compounds and organic electroluminescent devices comprising the same". Paragraph 0197-0202. . Retrieved 2020/07/28.