Benzofuran-2,3-dione

Base Information

• Chemical Name: Benzofuran-2,3-dione
• CAS No.: 4732-72-3
• Molecular Formula: C8H4O3
• Molecular Weight: 148.118
• Mol file: 4732-72-3.mol

Synonyms:2,3-benzofuranedione;3-oxobenzofuran-2-one;Coumarandione;2,3-dihydro-2,3-benzo[b]furandione;2,3-Benzofurandione;benzo[b]furan-2,3-dione;Benzofuran-2,3-dione;2,3-dihydrobenzofuran-2,3-dione;

Chemical Property of Benzofuran-2,3-dione

Chemical Property:

• Vapor Pressure: 0.00434mmHg at 25°C
• Melting Point: 120oC
• Refractive Index: 1.4500 (estimate)
• Boiling Point: 278.1°C at 760 mmHg
• Flash Point: 132.9°C
• PSA: 43.37000
• Density: 1.444
• LogP: 0.78830
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Benzofuran-2,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzofuran-2,3-dione

There total 11 articles about Benzofuran-2,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

benzofuran-2,3-dione 2-oxime → coumarandione (4732-72-3)

Guidance literature:

With hydrogenchloride; acetic acid; In water; Heating;

Reference yield: 50.0%

spiro[benzofuran-2(3H),2'-[1,3]dithian]-3-one → coumarandione (4732-72-3)

Guidance literature:

With N-chloro-succinimide; silver nitrate; In acetonitrile; at 0 ℃; for 0.0833333h;

DOI:10.1021/acs.joc.5b02350

Reference yield: 46.0%

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → coumarandione (4732-72-3)

Guidance literature:

indole-2,3-dione; With sodium hydroxide; sodium nitrite; In water; Cooling with ice;

With sulfuric acid; In water; at 60 ℃; Cooling with ice;

DOI:10.1246/bcsj.82.475

upstream raw materials:

2,2'-bi-benzofuranylidene-3,3'-dione

(2-hydroxyphenyl)oxoacetic acid

o-hydroxyacetophenone

indole-2,3-dione

Downstream raw materials:

2-(2-methoxy-benzoyl)-benzofuran-3-carboxylic acid ethyl ester

2-(2-hydroxyphenyl)-2-oxo-N-phenylacetamide

(2-hydroxy-phenyl)-phenylimino-acetic acid

2-m-toluoyl-benzofuran-3-carboxylic acid ethyl ester

Refernces

• 1、 -. "Preparing method and application for coumarone- 2,3- diketone oxime derivative". . . Retrieved 2017/04/21.
• 2、 Albertshofer, Klaus,Tan, Bin,Barbas III, Carlos F.. "Asymmetric construction of spirocyclopentenebenzofuranone core structures via highly selective phosphine-catalyzed [3 + 2] cycloaddition reactions". supporting information. p. 2958 - 2961. Retrieved 2013/07/26.