p-Toluidine Trifluoroacetamide

Base Information

• Chemical Name: p-Toluidine Trifluoroacetamide
• CAS No.: 350-96-9
• Molecular Formula: C9H8F3NO
• Molecular Weight: 203.164
• Hs Code.: 2924299090
• Mol file: 350-96-9.mol

Synonyms:p-Methyltrifluoroacetanilide;N-trifluoroacetyl-p-toluidine;N-(4-tolyl)trifluoroethaneimidoyl chloride;p-Toluidine Trifluoroacetamide;Acetamide,2,2,2-trifluoro-N-(4-methylphenyl);N-(4-methylphenyl)-2,2,2-trifluoroacetamide;2,2,2-trifluoro-N-p-tolylacetamide;N-(4-Methylpheenyl)trifluoroacetamide;2,2,2-trifluoro-4'-methylacetanilide;

Chemical Property of p-Toluidine Trifluoroacetamide

Chemical Property:

• Vapor Pressure: 0.0173mmHg at 25°C
• Melting Point: 111-112 °C
• Boiling Point: 254.4°C at 760 mmHg
• PKA: 10.06±0.70(Predicted)
• Flash Point: 107.7°C
• PSA: 29.10000
• Density: 1.309g/cm³
• LogP: 2.56880
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

p-ToluidineTrifluoroacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: p-Toluidine Trifluoroacetamide (cas# 350-96-9) is a compound useful in organic synthesis.

Technology Process of p-Toluidine Trifluoroacetamide

There total 21 articles about p-Toluidine Trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

p-toluidine (106-49-0,12221-03-3) + trifluoroacetic acid (76-05-1) → 2,2,2-trifluoro-N-(4-methylphenyl)acetamide (350-96-9)

Guidance literature:

With bis(trichloromethyl) carbonate; triethylamine; In dichloromethane; at 20 ℃; for 0.25h;

DOI:10.2174/157017811797249317

Reference yield: 96.0%

p-toluidine (106-49-0,12221-03-3) + GENERIC INORGANIC CATION; trifluoro-acetate → 2,2,2-trifluoro-N-(4-methylphenyl)acetamide (350-96-9)

Guidance literature:

for 0.1h; Irradiation;

DOI:10.1039/a807426g

Reference yield: 95.0%

trifluoroacetic acid (76-05-1) + S,S-dimethyl-4-methylanilinosulfonium picrate → 2,2,2-trifluoro-N-(4-methylphenyl)acetamide (350-96-9) + p-toluidine (106-49-0,12221-03-3) + dimethyl sulfoxide (67-68-5,8070-53-9)

Guidance literature:

at 50 ℃; for 5h;

DOI:10.1039/a803039a

upstream raw materials:

p-toluidine

trifluoroacetic anhydride

acetic anhydride

3,3,3-Trifluoro-1-phenyl-2-[(E)-p-tolylimino]-propan-1-ol

Downstream raw materials:

N-[4-(6-methylamino-pyrimidin-4-yloxy)-phenyl]-N'-[4-(4-H-piperazin-1-ylmethyl)-5-trifluoromethyl-phenyl]-urea

N-[4-(2-chloro-pyrimidin-4-yloxy)-phenyl]-N'-[4-(dimethylamino-methyl)-3-trifluoromethyl-phenyl]-urea

4-(4-tert-butyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl-amine

4-(4-isopropyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenylamine

Refernces

• 1、 Yoshida, Akira,Okamoto, Koichi,Yanagi, Tomoyuki,Nogi, Keisuke,Yorimitsu, Hideki. "Metal-free synthesis of biaryls from aryl sulfoxides and sulfonanilides via sigmatropic rearrangement". . . Retrieved 2020/05/20.
• 2、 Zhu, Longzhi,Le, Liyuan,Yan, Mingpan,Au, Chak-Tong,Qiu, Renhua,Kambe, Nobuaki. "Carbon-Carbon Bond Formation of Trifluoroacetyl Amides with Grignard Reagents via C(O)-CF3 Bond Cleavage". . p. 5635 - 5644. Retrieved 2019/05/10.