3-ethyladenine

Base Information

• Chemical Name: 3-ethyladenine
• CAS No.: 43003-87-8
• Molecular Formula: C₇H₉N₅
• Molecular Weight: 163.182
• Mol file: 43003-87-8.mol

Synonyms:3-Ethyl-3H-purin-6-ylamine;3-ethyladenine;

Chemical Property of 3-ethyladenine

Chemical Property:

• Vapor Pressure: 0.0158mmHg at 25°C
• Boiling Point: 256°C at 760 mmHg
• Flash Point: 108.6°C
• PSA: 69.62000
• Density: 1.49g/cm³
• LogP: 1.00960

Purity/Quality:

99%min ^*data from raw suppliers

3-Ethyl-adenine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Ethyl-adenine has been identified in urine of cigarette smokers

Technology Process of 3-ethyladenine

There total 4 articles about 3-ethyladenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

1,4,7,8-tetrahydro-4-iminothiazolo<2,3-b>purine (75018-20-1) → 3-ethyl-3H-purin-6-ylamine (43003-87-8)

Guidance literature:

With nickel; In methanol; for 5h; Heating;

Reference yield:

2-mercaptoadenine (3647-48-1) → 3-ethyl-3H-purin-6-ylamine (43003-87-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 36 percent / K₂CO₃ / various solvent(s) / 18 h / 40 °C

2: 20 percent / Raney nickel / methanol / 5 h / Heating

With nickel; potassium carbonate; In methanol;

Reference yield:

ethyl iodide (75-03-6) + 7H-purin-6-ylamine (73-24-5,71660-29-2,71660-30-5) → 9-ethyladenine (2715-68-6) + N7-Ethyladenine (24309-36-2) + 3-ethyl-3H-purin-6-ylamine (43003-87-8)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1.) DMF, 30 deg C, 1 h, 2.) DMF, 16 h;

upstream raw materials:

1,4,7,8-tetrahydro-4-iminothiazolo<2,3-b>purine

ethyl iodide

7H-purin-6-ylamine

2-mercaptoadenine

Downstream raw materials:

9-benzyl-3-ethyladenine hydrobromide

7-benzyl-3-ethyladenine hydrobromide

Refernces

• 1、 Montgomery, John A.,Thomas, Jeanette H.. "Dihydrothiazolopurines". . p. 583 - 584. Retrieved 2007/10/02.
• 2、 Lawley,Orr,Jarman. "Isolation and identification of products from alkylation of nucleic acids: ethyl- and isopropyl purines". . p. 73 - 84,77,78. Retrieved 2007/10/04.