CIS-4-METHYLCYCLOHEXANOL

Base Information

• Chemical Name: CIS-4-METHYLCYCLOHEXANOL
• CAS No.: 7731-28-4
• Molecular Formula: C7H14 O
• Molecular Weight: 114.188
• Hs Code.: 2906199090
• Mol file: 7731-28-4.mol

Synonyms:4-cis-Methylcyclohexanol;cis-4-Methyl-1-cyclohexanol; cis-4-Methylcyclohexanol

Chemical Property of CIS-4-METHYLCYCLOHEXANOL

Chemical Property:

• Vapor Pressure: 0.475mmHg at 25°C
• Melting Point: -10°C
• Refractive Index: 1.4610
• Boiling Point: 172-173°C
• PKA: 15.32±0.40(Predicted)
• Flash Point: 70°C
• PSA: 20.23000
• Density: 0,917 g/cm3
• LogP: 1.55740
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

cis-4-Methylcyclohexanol >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-38

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CIS-4-METHYLCYCLOHEXANOL

There total 46 articles about CIS-4-METHYLCYCLOHEXANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-methylcyclohexan-4-one (589-92-4) → trans-4-methylcyclohexan-1-ol (7731-29-5) + cis-4-methylcyclohexanol (7731-28-4)

Guidance literature:

With potassium 9-t-butyl-9-boratabicyclo<3.3.1>nonane; In tetrahydrofuran; at 0 ℃; Yield given. Title compound not separated from byproducts;

DOI:10.1016/0040-4039(88)85337-1

Reference yield: 88.4%

p-cresol (106-44-5) → trans-4-methylcyclohexan-1-ol (7731-29-5) + cis-4-methylcyclohexanol (7731-28-4) + 1-methylcyclohexan-4-one (589-92-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methyl cyclohexane; at 80 ℃; under 1125.09 Torr; Product distribution; Rate constant; other pressures, samples of Pd/C of the various sodium content;

DOI:10.1246/bcsj.65.824

Reference yield: 52.0%

5-(cis-4-methylcyclohexyloxy)thianthreniumyl perchlorate → thianthrene-5-oxide (2362-50-7) + 4-methylcyclohexene (591-47-9) + cis-4-methylcyclohexanol (7731-28-4) + Thianthrene (92-85-3)

Guidance literature:

With potassium iodide; In acetonitrile; for 2h; Product distribution;

DOI:10.1002/(SICI)1099-1395(199911)12:11<827::AID-POC198>3.0.CO;2-E

upstream raw materials:

p-cresol

aluminum isopropoxide

1-methylcyclohexan-4-one

trans-4-methylcyclohexan-1-ol

Downstream raw materials:

phthalic acid mono-(cis-4-methyl-cyclohexyl ester)

cis-4-methylcyclohexanol p-nitrobenzoate

1-methylcyclohexan-4-one

phenylcarbamic acid-(4-cis-methyl-cyclohexyl ester)

Refernces

• 1、 Gelis, Coralie,Heusler, Arne,Nairoukh, Zackaria,Glorius, Frank. "Catalytic Transfer Hydrogenation of Arenes and Heteroarenes". supporting information. p. 14090 - 14094. Retrieved 2020/10/19.
• 2、 Shinohara, Riku,Ogawa, Narihito,Kawashima, Hidehisa,Wada, Kyohei,Saito, Shun,Yamazaki, Takashi,Kobayashi, Yuichi. "SN2 Reaction of Diarylmethyl Anions at Secondary Alkyl and Cycloalkyl Carbons". . p. 1461 - 1478. Retrieved 2019/01/25.