4-CHLORO-4'-NITRODIPHENYL SULFIDE

Base Information

• Chemical Name: 4-CHLORO-4'-NITRODIPHENYL SULFIDE
• CAS No.: 21969-11-9
• Molecular Formula: C12H8ClNO2S
• Molecular Weight: 265.72
• Hs Code.: 2930909090
• Mol file: 21969-11-9.mol

Synonyms:4-(4-Chlorophenylthio)nitrobenzene;

Chemical Property of 4-CHLORO-4'-NITRODIPHENYL SULFIDE

Chemical Property:

• Melting Point: 83-84 °C
• Boiling Point: 435.5 °C at 760 mmHg
• Flash Point: 217.2 °C
• PSA: 71.12000
• Density: 1.41 g/cm³
• LogP: 4.92260

Purity/Quality:

99% ^*data from raw suppliers

4-CHLORO-4'-NITRODIPHENYL SULFIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-4'-NITRODIPHENYL SULFIDE

There total 28 articles about 4-CHLORO-4'-NITRODIPHENYL SULFIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-nitrobenzene iodide (636-98-6) + p-Chlorothiophenol (106-54-7) → 1-(4-chlorophenylthio)-4-nitrobenzene (21969-11-9)

Guidance literature:

With 4,4’‐bis(trimethylammoniummethyl)‐2,2’‐bipyridine; iron(III) chloride hexahydrate; potassium hydroxide; In water; for 24h; Reflux;

DOI:10.1039/b820790a

Reference yield: 98.0%

4-nitro-4’-chlorodiphenylsulfoxide (24535-53-3) → 1-(4-chlorophenylthio)-4-nitrobenzene (21969-11-9)

Guidance literature:

With ReOBr₂(hmpbta)(PPh₃); 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In tetrahydrofuran; for 1h; Reagent/catalyst; Time; chemoselective reaction; Reflux;

DOI:10.1002/ejoc.201301057

Reference yield: 97.0%

p-Chlorothiophenol (106-54-7) + 4-Fluoronitrobenzene (350-46-9,178603-76-4) → 1-(4-chlorophenylthio)-4-nitrobenzene (21969-11-9)

Guidance literature:

With potassium fluoride impregnated on clinoptilolite; air; In dimethyl sulfoxide; at 110 - 115 ℃; for 2h;

DOI:10.2174/1386207311316050002

upstream raw materials:

potassium p-chlorobenzene thiolate

4-chlorobenzonitrile

p-Chlorothiophenol

1-Chloro-4-iodobenzene

Downstream raw materials:

4-(4-chlorophenylthio)aniline

4-(4-chloro-benzenesulfonyl)-aniline

p-chlorobenzenesulphinamide

di(p-nitrophenyl) disulfide

Refernces

• 1、 Yu, Shao-Qiang,Liu, Na,Liu, Ming-Guo,Wang, Long. "Synthesis of diaryl sulfides based on copper-doped OMS-2". . p. 237 - 241. Retrieved 2020/11/30.
• 2、 Pinkerton, Anthony B.,Sessions, E. Hampton,Hershberger, Paul,Maloney, Patrick R.,Peddibhotla, Satyamaheshwar,Hopf, Meghan,Sergienko, Eduard,Ma, Chen-Ting,Smith, Layton H.,Jackson, Michael R.,Tanaka, Jun,Tsuji, Takashi,Akiu, Mayuko,Cohen, Steven E.,Nakamura, Tsuyoshi,Gardell, Stephen J.. "Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators". . . Retrieved 2021/04/27.