Emorfazone

Base Information

• Chemical Name: Emorfazone
• CAS No.: 38957-41-4
• Molecular Formula: C11H17N3O3
• Molecular Weight: 239.274
• Hs Code.: 2934999090
• European Community (EC) Number: 254-220-9
• UNII: V93U9DH62C
• DSSTox Substance ID: DTXSID0022981
• Nikkaji Number: J3.186K
• Wikidata: Q27291687
• NCI Thesaurus Code: C73085
• Metabolomics Workbench ID: 155697
• ChEMBL ID: CHEMBL2103954
• Mol file: 38957-41-4.mol

Synonyms:4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone;emorfazone;M 73101;M-73101;M73101

Chemical Property of Emorfazone

Chemical Property:

• Vapor Pressure: 1.46E-05mmHg at 25°C
• Melting Point: 89-91°
• Refractive Index: 1.5700 (estimate)
• Boiling Point: 366.5°C at 760 mmHg
• Flash Point: 175.4°C
• PSA: 56.59000
• Density: 1.27g/cm³
• LogP: 0.08060
• XLogP3: 0
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 239.12699141
• Heavy Atom Count: 17
• Complexity: 359

Purity/Quality:

95-99% ^*data from raw suppliers

EMORFAZONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=C(C=NN(C1=O)C)N2CCOCC2
• Description: Emorfazone is an analgesic agent with a potency similar to aminopyrine, useful in the treatment of low back pain and similar musculoskeletal disorders.
• Uses: Emorfazone has been known to comprise of 5α-?reductase inhibitor. It consists of postsurgical adhesion inhibitors that contain anti-inflammatory agents and anticoagulants and hyaluronate.

Technology Process of Emorfazone

There total 1 articles about Emorfazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ emorfazone (38957-41-4)

Guidance literature:

entspr. 4-Chlor-pyridazinon, Ethanol (Na);

Reference yield: 14.0%

emorfazone (38957-41-4) → 4-ethoxycarbonyl-2-methyl-4-morpholino-3(2H)-pyrazolone (116614-72-3) + 5-(2,3-dihydro-1,4-oxazin-4-yl)-4-ethoxy-2-methyl-3(2H)-pyridazinone (116614-71-2) + diethyl 1,1'-dimethyl-5,5'-dioxo-1,1',5,5'-tetrahydro-4H,4'H-[4,4'-bipyrazole]-4,4'-dicarboxylate (116614-73-4) + 4-ethoxy-5-(2-hydroxyethylamino)-2-methyl-3(2H)-pyridazinone (67911-04-0)

Guidance literature:

With 1,3,6,8-tetra-n-butylpyrimido<5,4-g>pteridine-2,4,5,7(1H,3H,6H,8H)-tetrone 10-oxide; In acetonitrile; for 0.5h; Ambient temperature; Irradiation;

DOI:10.1248/cpb.36.1714

Downstream raw materials:

4-ethoxycarbonyl-2-methyl-4-morpholino-3(2H)-pyrazolone

5-(2,3-dihydro-1,4-oxazin-4-yl)-4-ethoxy-2-methyl-3(2H)-pyridazinone

diethyl 1,1'-dimethyl-5,5'-dioxo-1,1',5,5'-tetrahydro-4H,4'H-[4,4'-bipyrazole]-4,4'-dicarboxylate

4-ethoxy-5-(2-hydroxyethylamino)-2-methyl-3(2H)-pyridazinone