METHYL 3-HYDROXYPROPANOATE

Base Information

• Chemical Name: METHYL 3-HYDROXYPROPANOATE
• CAS No.: 6149-41-3
• Molecular Formula: C4H8O3
• Molecular Weight: 104.106
• Hs Code.: 2918199090
• Mol file: 6149-41-3.mol

Synonyms:Hydracrylicacid, methyl ester (7CI,8CI);3-Hydroxypropanoic acid methyl ester;Methyl3-hydroxypropanoate;Methyl 3-hydroxypropionate;Methyl hydracrylate;Methyl b-hydroxypropionate;b-Hydroxypropionic acid methylester;

Chemical Property of METHYL 3-HYDROXYPROPANOATE

Chemical Property:

• Vapor Pressure: 0.263mmHg at 25°C
• Melting Point: 147-148 °C(Solv: benzene (71-43-2); cyclohexane (110-82-7))
• Refractive Index: 1.414
• Boiling Point: 180.5 °C at 760 mmHg
• PKA: 13.89±0.10(Predicted)
• Flash Point: 72.6 °C
• PSA: 46.53000
• Density: 1.089 g/cm³
• LogP: -0.45820
• Storage Temp.: 2-8°C
• Solubility.: Chloroform, Methanol

Purity/Quality:

98%, ^*data from raw suppliers

Methyl3-hydroxypropanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 3-HYDROXYPROPANOATE

There total 21 articles about METHYL 3-HYDROXYPROPANOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.08%

oxirane (75-21-8,99932-75-9) + Tetraethylene glycol dimethyl ether (143-24-8) + carbon monoxide (201230-82-2) → 2-methoxy-ethanol (109-86-4,95507-80-5) + methyl ester (3-hydroxy) propionic acid (6149-41-3) + methyl β-(β-hydroxypropionyloxy)propionate (27313-49-1) + acetaldehyde (75-07-0,9002-91-9)

Guidance literature:

3-HYDROXYPYRIDINE; dicobalt octacarbonyl; at 75 ℃; for 4h; under 45004.5 Torr; Heating / reflux;

Reference yield: 40.2%

oxirane (75-21-8,99932-75-9) + methanol (67-56-1) + carbon monoxide (201230-82-2) → 1,1-dimethoxyethane (534-15-6) + 2-methoxy-ethanol (109-86-4,95507-80-5) + methyl ester (3-hydroxy) propionic acid (6149-41-3) + methyl β-(β-hydroxypropionyloxy)propionate (27313-49-1) + acetaldehyde (75-07-0,9002-91-9)

Guidance literature:

1H-imidazole; dicobalt octacarbonyl; at 60 - 80 ℃; for 3 - 4h; under 25502.6 - 60006 Torr; Heating / reflux;

Reference yield:

Dimethyl 2-oxosuccinate (25007-54-9) → dimethyl (S)-malate (617-55-0) + methyl ester (3-hydroxy) propionic acid (6149-41-3) + (R)-dimethyl malate (70681-41-3)

Guidance literature:

With baker's yeast; Title compound not separated from byproducts; Ambient temperature;

DOI:10.1016/S0957-4166(99)00286-4

upstream raw materials:

methanol

potassium formate

methyl 3-chloropropionate

β-Propiolactone

Downstream raw materials:

acetic acid methyl ester

acrylic acid methyl ester

acrylic acid

methanol

Refernces

• 1、 -. "CHEMICAL COMPOUNDS". Paragraph 0564-0565. . Retrieved 2014/12/09.
• 2、 Guo, Zhenmei,Wang, Hengsheng,Lv, Zhiguo,Wang, Zhihui,Nie, Tao,Zhang, Weiwei. "Catalytic performance of [Bmim][Co(CO)4] functional ionic liquids for preparation of 1,3-propanediol by coupling of hydroesterification- hydrogenation from ethylene oxide". experimental part. p. 3668 - 3672. Retrieved 2011/12/02.