Technology Process of 1-(methylsulfonyl)indole-3-carboxaldehyde
There total 9 articles about 1-(methylsulfonyl)indole-3-carboxaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
- Guidance literature:
-
With
tris(triphenylphosphine)ruthenium(II) chloride; oxygen;
In
1,2-dichloro-ethane;
at 50 - 60 ℃;
for 4h;
DOI:10.1246/bcsj.61.310
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 96 percent / H2 / 5percent Pd/C / ethyl acetate / 15 h / Ambient temperature
2: 85 percent / Et3N / CH2Cl2 / 3 h / Ambient temperature
3: 94 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / CH2Cl2 / 15 h / Heating
4: 85 percent / NaBr / acetonitrile; H2O / 2.8 h / Ambient temperature; electrolysis
5: 80 percent / RuCl2(PPh3)3, O2 / 1,2-dichloro-ethane / 4 h / 50 - 60 °C
With
tris(triphenylphosphine)ruthenium(II) chloride; hydrogen; oxygen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium bromide;
palladium on activated charcoal;
In
dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1246/bcsj.61.310