2,4-Dichloro-5-fluorobenzoyl chloride

Base Information

• Chemical Name: 2,4-Dichloro-5-fluorobenzoyl chloride
• CAS No.: 86393-34-2
• Molecular Formula: C7H2 Cl3 F O
• Molecular Weight: 227.45
• Hs Code.: 2916399090
• European Community (EC) Number: 428-390-1,622-285-6
• DSSTox Substance ID: DTXSID60371627
• Wikidata: Q72466250
• Mol file: 86393-34-2.mol

Synonyms:2,4-Dichloro-5-fluorobenzoyl chloride;86393-34-2;2,4-dichloro-5-fluorobenzoylchloride;2,4-dichloro-5-fluoro-benzoyl chloride;EC 428-390-1;MFCD00075341;24-Dichloro-5-fluorobenzoyl chloride;C7H2Cl3FO;SCHEMBL1180396;DTXSID60371627;RPZXUSJCSDQNTE-UHFFFAOYSA-N;AMY40418;2,4-Dichlor-5-fluor-benzoylchlorid;AKOS015850031;JS-4138;CS-0267893;D4380;FT-0610011;2,4-Dichloro-5-fluorobenzoyl chloride, 97%;EN300-1459127;A841634

Chemical Property of 2,4-Dichloro-5-fluorobenzoyl chloride

Chemical Property:

• Appearance/Colour: Colorless to pale yellow liquid
• Vapor Pressure: 0.0309mmHg at 25°C
• Refractive Index: n20/D 1.572(lit.)
• Boiling Point: 244.1 °C at 760 mmHg
• Flash Point: >110 ºC
• PSA: 17.07000
• Density: 1.568
• LogP: 3.51150
• Sensitive.: Moisture Sensitive
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 225.915526
• Heavy Atom Count: 12
• Complexity: 188

Purity/Quality:

99% ^*data from raw suppliers

2,4-Dichloro-5-fluorobenzoyl Chloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34-36/37
• Safety Statements: 26-27-28-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=CC(=C1F)Cl)Cl)C(=O)Cl

Technology Process of 2,4-Dichloro-5-fluorobenzoyl chloride

There total 9 articles about 2,4-Dichloro-5-fluorobenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.8%

1,5-dichloro-2-fluoro-4-(trichloromethyl)benzene → 2,4-dichloro-5-fluorobenzoyl chloride (86393-34-2)

Guidance literature:

With iron(III) chloride; water; at 130 ℃; for 10h; Temperature;

Reference yield: 99.1%

2,4-dichloro-5-fluoro-benzoic acid (86522-89-6) → 2,4-dichloro-5-fluorobenzoyl chloride (86393-34-2)

Guidance literature:

With bis(trichloromethyl) carbonate; In toluene; at 110 ℃; Industrial scale; Green chemistry;

Reference yield: 98.8%

carbon dioxide (124-38-9,18923-20-1) + 1,3-dichloro-4-fluorobenzene (1435-48-9) → 2,4-dichloro-5-fluorobenzoyl chloride (86393-34-2)

Guidance literature:

With Cationic resin catalyst; In tetrachloromethane; at 40 - 60 ℃; for 5h; under 15001.5 Torr; Pressure; Temperature; Reagent/catalyst;

upstream raw materials:

2,4-dichloro-5-fluoro-benzoic acid

1,3-dichloro-4-fluorobenzene

tetrachloromethane

2,4-dichloro-5-fluoroacetophenone

Downstream raw materials:

diethyl 2,4-dichloro-5-fluoro-benzoyl-malonate

2,4-dichloro-5-fluoro-benzoic acid N'-(2,3,4,5-tetrafluoro-benzoyl)-hydrazide

2-chloro-4,5-difluoro-benzoic acid N'-(2,4-dichloro-5-fluoro-benzoyl)-hydrazide

2,4,5-trifluoro-benzoic acid N'-(2,4-dichloro-5-fluoro-benzoyl)-hydrazide

Refernces

• 1、 -. "Environment-friendly production process of 2, 4-dichloro-5-fluorobenzoyl chloride". . . Retrieved 2020/08/22.
• 2、 -. "Preparation method for fluoroquinolones intermediate 2,4-dichloro-5-fluorobenzoyl chloride". . . Retrieved 2019/05/20.