Benzeneethanesulfonic acid, b-oxo-, methyl ester

Base Information

• Chemical Name: Benzeneethanesulfonic acid, b-oxo-, methyl ester
• CAS No.: 131353-62-3
• Molecular Formula: C9H10O4S
• Molecular Weight: 214.242
• Mol file: 131353-62-3.mol

Synonyms:

Chemical Property of Benzeneethanesulfonic acid, b-oxo-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneethanesulfonic acid, b-oxo-, methyl ester

There total 5 articles about Benzeneethanesulfonic acid, b-oxo-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + benzoylmethanesulfonic acid (4496-92-8) → methyl 2-oxo-phenylethane-1-sulfonate (131353-62-3)

Guidance literature:

In diethyl ether; at -60 - 25 ℃;

Reference yield:

Methyl methanesulfonate (66-27-3) + benzoyl chloride (98-88-4) → methyl 2-oxo-phenylethane-1-sulfonate (131353-62-3)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, -78 deg C, 20 min, 2.) 30 min;

DOI:10.1021/ja00006a052

Reference yield:

1-styrenyloxytrimethylsilane (13735-81-4) → methyl 2-oxo-phenylethane-1-sulfonate (131353-62-3)

Guidance literature:

Multi-step reaction with 3 steps

1: SO₂; (t-Bu)Me₂SiOSO₂CF₃ / acetonitrile / -78 °C

2: Br₂ / 1 h / -20 °C

3: 1 h / -20 °C

With t-butyldimethylsiyl triflate; sulfur dioxide; bromine; In acetonitrile;

DOI:10.1021/jo049047j

upstream raw materials:

Methyl methanesulfonate

benzoyl chloride

diazomethane

benzoylmethanesulfonic acid

Refernces

• 1、 Efimova,Lipina,Berkova,Pozdnyakov. "Alkyl β-Oxoalkanesulfonates. I. Synthesis and Structure". . p. 1424 - 1428. Retrieved 2007/10/03.