Febuverine

Base Information

• Chemical Name: Febuverine
• CAS No.: 7077-33-0
• Molecular Formula: C₂₈H₃₈N₂O₄
• Molecular Weight: 466.621
• Mol file: 7077-33-0.mol

Synonyms:Butyricacid, 2-phenyl-, 1,4-piperazinediyldiethylene ester (6CI,8CI); 1,4-Piperazinediethanol,bis(2-phenylbutyrate) (ester); 1,4-Piperazinediethanol di(2-phenylbutyrateester); Febuverine; PG 430; Phebutazine; Spasmo-Sapos

Chemical Property of Febuverine

Chemical Property:

• Vapor Pressure: 1.21E-12mmHg at 25°C
• Boiling Point: 561.7°C at 760 mmHg
• PKA: 6.44±0.10(Predicted)
• Flash Point: 293.5°C
• PSA: 59.08000
• Density: 1.096g/cm³
• LogP: 3.95380

Purity/Quality:

97% ^*data from raw suppliers

FEBUVERINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Febuverine

There total 4 articles about Febuverine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperazine (110-85-0) + (+/-)-2-phenyl-butyric acid-(2-chloro-ethyl ester) (100388-72-5) → 1.4-Bis-<2-(2-phenyl-butyryl-oxy)-ethyl>-piperazin (7077-33-0)

Guidance literature:

at 130 ℃;

Reference yield:

2-Phenylbutyryl chloride (36854-57-6) → 1.4-Bis-<2-(2-phenyl-butyryl-oxy)-ethyl>-piperazin (7077-33-0)

Guidance literature:

Multi-step reaction with 2 steps

2: ethanol; NaHCO₃

With ethanol; sodium hydrogencarbonate;

DOI:10.1002/hlca.19590420406

Reference yield:

1,4-bis(2-chloroethyl)piperazine dihydrochloride (1428-92-8,63980-44-9,93335-18-3) + 2-Phenylbutyric acid (90-27-7) → 1.4-Bis-<2-(2-phenyl-butyryl-oxy)-ethyl>-piperazin (7077-33-0)

Guidance literature:

With Trichloroethylene; potassium carbonate;

upstream raw materials:

piperazine

(+/-)-2-phenyl-butyric acid-(2-chloro-ethyl ester)

1,4-bis(2-chloroethyl)piperazine dihydrochloride

2-Phenylbutyric acid

Refernces