3,5-Diphenylpyridine

Base Information

• Chemical Name: 3,5-Diphenylpyridine
• CAS No.: 92-07-9
• Molecular Formula: C17H13 N
• Molecular Weight: 231.297
• Hs Code.: 2933399090
• European Community (EC) Number: 202-123-7
• DSSTox Substance ID: DTXSID30238814
• Nikkaji Number: J182.085K
• Wikidata: Q83121148
• ChEMBL ID: CHEMBL69058
• Mol file: 92-07-9.mol

Synonyms:2,5-diphenylpyridine;2,5DPhPy;2,6-diphenylpyridine;2,6-DPhPy;3,5-diphenylpyridine;3,5DPhPy

Chemical Property of 3,5-Diphenylpyridine

Chemical Property:

• Vapor Pressure: 4.15E-06mmHg at 25°C
• Melting Point: 193-194 °C
• Boiling Point: 395.6°C at 760 mmHg
• PKA: 4.47±0.20(Predicted)
• Flash Point: 175.3°C
• PSA: 12.89000
• Density: 1.084g/cm³
• LogP: 4.41560
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 231.104799419
• Heavy Atom Count: 18
• Complexity: 214

Purity/Quality:

99% ^*data from raw suppliers

3,5-Diphenylpyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC(=CN=C2)C3=CC=CC=C3

Technology Process of 3,5-Diphenylpyridine

There total 93 articles about 3,5-Diphenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3,5-dibromopyridine (625-92-3) + 4-methyl-2,6-dioxo-8-phenylhexahydro-[1,3,2]oxazaborolo[2,3-b][1,3,2]oxazaborol-4-ium-8-uide (109674-45-5) → 3,5-diphenylpyridine (92-07-9)

Guidance literature:

With potassium phosphate; [Pd(η(5)-C5H5)Fe(η(5)-C5H3-C(CH3)=N-C6H4-4-CH3)Cl(P(C6H5)3)]; In ethanol; water; at 90 ℃; for 4h; Inert atmosphere; Schlenk technique; Green chemistry;

DOI:10.1039/c4ra07486f

Reference yield: 95.0%

3,5-dichloropyridine (2457-47-8) + phenylboronic acid (98-80-6) → 3,5-diphenylpyridine (92-07-9)

Guidance literature:

With sodium hydroxide; polyaniline-supported palladium; In water; at 100 ℃; for 6h;

DOI:10.1002/anie.200701389

Reference yield: 93.0%

phenylacetaldehyde (122-78-1) → 3,5-diphenylpyridine (92-07-9)

Guidance literature:

With ammonium cerium (IV) nitrate; copper (II) trifluoroacetate hydrate; water; In N,N-dimethyl-formamide; at 80 ℃; for 12h; under 760.051 Torr; Reagent/catalyst; Temperature; Inert atmosphere;

DOI:10.1021/ol5035996

upstream raw materials:

3,5-Diphenyl-piperidine

3,5-diphenyl-pyridine-2-carboxylic acid

phenylacetaldehyde

isobutyraldehyde

Downstream raw materials:

1-methyl-3,5-diphenyl-pyridinium; iodide

Refernces

• 1、 Komatsu. "-". . p. 4589. Retrieved 1976.
• 2、 Chen, Xingshuo,Wei, Zhenwei,Huang, Kai-Hung,Uehling, Mycah,Wleklinski, Michael,Krska, Shane,Makarov, Alexey A.,Nowak, Timothy,Cooks, R. Graham. "Pd Reaction Intermediates in Suzuki-Miyaura Cross-Coupling Characterized by Mass Spectrometry". . . Retrieved 2022/02/09.
• 3、 Ashiq, Muhammad Naeem,Hua, Ruimao,Iqbal, Muhammad Asif,Mehmood, Hina. "Base-promoted one-pot synthesis of pyridine derivatives via aromatic alkyne annulation using benzamides as nitrogen source". supporting information. . Retrieved 2021/11/08.