D-Glutamic acid, N-[4-[[(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benz oyl]-

Base Information

• Chemical Name: D-Glutamic acid, N-[4-[[(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benz oyl]-
• CAS No.: 15574-38-6
• Molecular Formula: C₁₉H₂₁N₇O₆
• Molecular Weight: 443.419
• Mol file: 15574-38-6.mol

Synonyms:

Chemical Property of D-Glutamic acid, N-[4-[[(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benz oyl]-

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of D-Glutamic acid, N-[4-[[(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benz oyl]-

There total 2 articles about D-Glutamic acid, N-[4-[[(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benz oyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

folate (59-30-3) → dihydrofolic acid (15574-38-6,4033-27-6)

Guidance literature:

With sodium hydroxide; sodium dithionite; In water; for 3.33333h; Ambient temperature;

DOI:10.1016/S0040-4020(01)87409-3

Reference yield:

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + dihydropteroate (2134-76-1) → dihydrofolic acid (15574-38-6,4033-27-6)

Guidance literature:

With potassium chloride; glycerol; ATP; sodium chloride; magnesium chloride; diothiothreitol; In aq. buffer; at 37 ℃; for 1h; pH=9.5; Reagent/catalyst; Enzymatic reaction;

DOI:10.1128/AAC.01775-13

Reference yield:

dihydrofolic acid (15574-38-6,4033-27-6) → tetrahydrofolic acid (135-16-0)

Guidance literature:

With wild-type dihydrofolatereductase; 2-hydroxyethanethiol; NADPH; In aq. phosphate buffer; at 37 ℃; pH=7.4; Reagent/catalyst;

DOI:10.1128/AAC.01161-13

upstream raw materials:

folate

L-glutamic acid

dihydropteroate

Downstream raw materials:

(6S,S)-5,6,7,8-tetrahydrofolic acid

(6-R,S)-5,6,7,8-tetrahydrofolate

(6R)-5,10-methylylidenetetrahydrofolic acid chloride

tetrahydrofolic acid

Refernces

• 1、 -. "Method for preparing L-5-calcium methyl tetrahydrofolate through enzymic method". Page/Page column 5-8. . Retrieved 2019/05/04.
• 2、 Rees, Lilias,Valente, Edward,Suckling, Colin J.,Wood, Hamish C. S.. "ASYMMETRIC REDUCTION OF DIHYDROFOLATE USING DIHYDROFOLATE REDUCTASE AND CHIRAL BORON-CONTAINING COMPOUNDS". . p. 117 - 136. Retrieved 2007/10/02.