(+)-Menthol

Base Information Edit

Chemical Name:(+)-Menthol
CAS No.:15356-60-2
Molecular Formula:C10H20O
Molecular Weight:156.268
Hs Code.:29061100
European Community (EC) Number:201-939-0,239-387-8,239-388-3
UNII:C6B1OE8P3W
DSSTox Substance ID:DTXSID8029733
Nikkaji Number:J9.252E
Wikidata:Q27084428
RXCUI:1648123
Pharos Ligand ID:D4N6NA3R9J2J
Metabolomics Workbench ID:126880
ChEMBL ID:CHEMBL2106989
Mol file:15356-60-2.mol

Synonyms:(+)-Menthol;15356-60-2;d-Menthol;(1S,2R,5S)-(+)-Menthol;(1S,2R,5S)-Menthol;Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1S,2R,5S)-;(1S,2R,5S)-2-Isopropyl-5-methylcyclohexanol;Hexahydrothymol;Menthol, (+)-;(1S,2R,5S)-5-methyl-2-propan-2-ylcyclohexan-1-ol;(1S,2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-ol;Menthol, (1S,3S,4R)-(+)-;UNII-C6B1OE8P3W;C6B1OE8P3W;rac-Menthol;DTXSID8029733;CHEBI:76306;(+)-(1S,2R,5S)-menthol;(+)-(1S,3S,4R)-menthol;p-Menthan-3-ol;EINECS 239-387-8;(1S,2R,5S)-5-methyl-2-(1-methylethyl)cyclohexanol;89-78-1;EC 239-387-8;Menthol, racemic;3-p-Menthanol;D - menthol;MFCD00062983;Racementhol [BAN:INN];(+)-p-Menthan-3-ol;Fisherman's friend lozenges;(1R,2S,5R)-Menthol;Menthol, cis-1,3,trans-1,4-;Fancol menthol;Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1.alpha.,2.beta.,5.alpha.)-;(DL)-Menthol;(+) - menthol;(.+/-.)-Menthol;(1S)-(+)-menthol;(+/-)-Menthol racemic;MENTHOL, D-;Ciclohexanol, 5-metil-2-(1-metiletil)-, (1r, 2s, 5r)-rel-;SCHEMBL521946;DTXCID409733;GTPL2471;CHEMBL2106989;(1s, 2r, 5s)-(+)-menthol;Menthol, (1S,3S,4R)-()-;Tox21_201043;AKOS006281173;CS-W017993;DB11344;HY-W017277;NCGC00248905-01;NCGC00258596-01;AS-69562;(1S,2R,5S)-(+)-Menthol, 99%;CAS-15356-60-2;M0826;M3170;EN300-92162;A815982;(1S,2R,5S)-2-Isopropyl-5-methylcyclohexan-1-ol;(1S,2R,5S)-5-methyl-2-propan-2-yl-1-cyclohexanol;Q27084428;(1S,2R,5S)-5-methyl-2-propan-2-yl-cyclohexan-1-ol;F8889-8741;Z1198149783;5.alpha.-Methyl-2.beta.-(1.alpha.-methylethyl)cyclohexanol;Cyclohexanol,5-methyl-2-(1-methylethyl)-,(1S,2R,5S)-;2-Isopropyl-5-methylcyclohexanol, (1.alpha.,2.beta.,5.alpha.)-;5-Methyl-2-(1-methylethyl)cyclohexanol, (1.alpha.,2.beta.,5.alpha.)-;Cyclohexanol, 2-isopropyl-5-methyl-, (1.alpha.,2.beta.,5.alpha.)-;Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1S-(1alpha,2beta,5alpha))-;(+)-Menthol, puriss. p.a., terpene standard for GC, >=99.0% (sum of enantiomers, GC);Cyclohexanol, 5-methyl-2-(1-methylethyl)-, [1S-(1.alpha.,2.beta.,5.alpha.)]-

Suppliers and Price of (+)-Menthol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(1S,2R,5S)-(+)-Menthol
10 g
$ 65.00

TCI Chemical
(+)-Menthol >99.0%(GC)
100g
$ 115.00

TCI Chemical
(+)-Menthol >99.0%(GC)
25g
$ 46.00

SynQuest Laboratories
D-Menthol
5 g
$ 95.00

Sigma-Aldrich
(1S,2R,5S)-(+)-Menthol 99%
10g
$ 59.10

Sigma-Aldrich
(+)-Menthol solution certified reference material, 2000?μg/mL in methanol, ampule of 1?mL
1 mL
$ 77.60

Sigma-Aldrich
(+)-Menthol solution certified reference material, 2000 μg/mL in methanol, ampule of 1 mL
crm40474
$ 75.20

Sigma-Aldrich
(1S,2R,5S)-(+)-Menthol 99%
50g
$ 205.00

Medical Isotopes, Inc.
(1S,2R,5S)-(+)-Menthol
5 g
$ 620.00

Matrix Scientific
(1S,2R,5S)-5-Methyl-2-(propan-2-yl)cyclohexan-1-ol 95%+
1g
$ 101.00

Total 64 raw suppliers

Chemical Property of (+)-Menthol Edit

Chemical Property:

Vapor Pressure:0.8 mm Hg ( 20 °C)
Melting Point:43-44 °C(lit.)
Refractive Index:50 ° (C=10, EtOH)
Boiling Point:215.383 °C at 760 mmHg
PKA:15.30±0.60(Predicted)
Flash Point:93.333 °C
PSA：20.23000
Density:0.89 g/cm³
LogP:2.43950
Storage Temp.:2-8°C
Solubility.:Chloroform (Slightly), Methanol (Slightly)
Water Solubility.:Soluble in methanol (almost transparency), chloroform, alcohols, water (456 mg/L at 25°C), and ether.
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:156.151415257
Heavy Atom Count:11
Complexity:120

Purity/Quality:

99.9% ^*data from raw suppliers

(1S,2R,5S)-(+)-Menthol ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 37/38-41
Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Chemical Classes:Biological Agents -> Plant Oils and Extracts
Canonical SMILES:CC1CCC(C(C1)O)C(C)C
Isomeric SMILES:C[C@H]1CC[C@@H]([C@H](C1)O)C(C)C
Description (+)-Menthol is a monoterpene alcohol that has been found in Cannabis and has antifungal activity. It inhibits the growth of F. verticillioides (MIC = 1.5 mM). Unlike (–)-menthol, (+)-menthol does not exhibit analgesia, antibacterial, anticancer, or cholinesterase inhibitory activities.
Uses (1S,2R,5S)-(+)-menthol can undergo acylation with acid anhydrides in the presence of trimethylsilyl trifluoromethanesulfonate to form the corresponding acylated products. (+)-MENTHOL is used for oral gel patch or film containing herb extracts or Chinese medicine, fruit extract, spearmint, and menthol for smoking cessation.

Technology Process of (+)-Menthol

There total 120 articles about (+)-Menthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.58%