methyl 3-(2-furyl)-3-oxo-propanoate

Base Information

• Chemical Name: methyl 3-(2-furyl)-3-oxo-propanoate
• CAS No.: 615-06-5
• Molecular Formula: C8H8 O4
• Molecular Weight: 168.149
• Hs Code.: 2932190090
• Mol file: 615-06-5.mol

Synonyms:2-Furanpropionicacid, b-oxo-, methyl ester (8CI); Methyl2-furoylacetate; Methyl 3-(2-furyl)-3-oxopropionate; Methyl 3-oxo-3-(2-furanyl)propanoate;NSC 21608

Chemical Property of methyl 3-(2-furyl)-3-oxo-propanoate

Chemical Property:

• Vapor Pressure: 0.0461mmHg at 25°C
• Boiling Point: 236.9°C at 760 mmHg
• PKA: 9.70±0.46(Predicted)
• Flash Point: 97.1°C
• PSA: 56.51000
• Density: 1.198g/cm³
• LogP: 1.02540
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

Methyl2-furoylacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-(2-furyl)-3-oxo-propanoate

There total 11 articles about methyl 3-(2-furyl)-3-oxo-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.4%

1-(2-furyl)-1-ethanone (1192-62-7,80145-44-4) + carbonic acid dimethyl ester (616-38-6) → 3-furan-2-yl-3-oxo-propionic acid methyl ester (615-06-5)

Guidance literature:

DOI:10.1246/cl.1999.1055

Reference yield: 57.0%

furfural (98-01-1) + methyl diazoacetate (6832-16-2) → 3-furan-2-yl-3-oxo-propionic acid methyl ester (615-06-5)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1007/BF01455486

Reference yield:

2-furanoic acid (88-14-2) + Malonic acid monomethyl ester (16695-14-0) + magnesium ethylate (2414-98-4) → 3-furan-2-yl-3-oxo-propionic acid methyl ester (615-06-5)

Guidance literature:

With hydrogenchloride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol;

upstream raw materials:

2-furoic acid methyl ester

acetic acid methyl ester

Ethyl 2-furoate

furfural

Downstream raw materials:

methyl [2,2'-bifuran]-3-carboxylate

(4-(5-(furan-2-yl)-2-phenylpyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl)(furan-3-yl)methanone

Refernces

• 1、 Nakagawa, Satoshi,Haruna, Noriko,Acosta, Delicia E.,Endo, Tadateru,Sugimura, Takashi,Tai, Akira. "Enantio-differentiating hydrogenation of methyl 2-furoylacetate and its analogs over tartaric acid-modified Raney nickel". . p. 1055 - 1056. Retrieved 1999.
• 2、 Wang, Zheng-Hai,Wang, Dong-Hui. "Cu-Catalyzed Synthesis of Benzoxazole with Phenol and Cyclic Oxime". supporting information. p. 782 - 785. Retrieved 2022/01/20.
• 3、 Chen, Chien-Tien,Maity, Nabin Ch.,Agarwal, Rachit,Lai, Chien-Fu,Liao, Yiya,Yu, Wei-Ru. "Chiral Vanadyl(V) Complexes Enable Efficient Asymmetric Reduction of β-Ketoamides: Application toward (S)-Duloxetine". supporting information. p. 6408 - 6419. Retrieved 2020/07/14.