3,4,5-TRIMETHOXYPHENYLACETONE

Base Information

• Chemical Name: 3,4,5-TRIMETHOXYPHENYLACETONE
• CAS No.: 16603-18-2
• Molecular Formula: C12H16 O4
• Molecular Weight: 224.257
• Hs Code.: 2914509090
• Mol file: 16603-18-2.mol

Synonyms:2-Propanone,(3,4,5-trimethoxyphenyl)- (6CI,7CI); (3,4,5-Trimethoxyphenyl)-2-propanone;1-(3,4,5-Trimethoxyphenyl)propan-2-one; 3,4,5-Trimethoxybenzyl methyl ketone;3,4,5-Trimethoxyphenylacetone

Chemical Property of 3,4,5-TRIMETHOXYPHENYLACETONE

Chemical Property:

• Vapor Pressure: 0.000451mmHg at 25°C
• Melting Point: 58-62°C
• Boiling Point: 314.9°Cat760mmHg
• Flash Point: 136.1°C
• PSA: 44.76000
• Density: 1.078g/cm³
• LogP: 1.84390
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1-(3,4,5-Trimethoxyphenyl)propan-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4,5-TRIMETHOXYPHENYLACETONE

There total 21 articles about 3,4,5-TRIMETHOXYPHENYLACETONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(E)-1,2,3-trimethoxy-5-(2-nitroprop-1-enyl)benzene (38059-94-8) → (3,4,5-trimethoxyphenyl)acetone (16603-18-2)

Guidance literature:

With iron; In acetic acid; at 20 ℃; for 0.5h;

DOI:10.1021/acs.joc.5b02712

Reference yield: 85.0%

1,2,3-trimethoxy-5-(2-nitro-propyl)benzene → (3,4,5-trimethoxyphenyl)acetone (16603-18-2)

Guidance literature:

With hydrogenchloride; iron; In methanol; water; for 0.5h; Heating;

DOI:10.1081/SCC-200051681

Reference yield: 84.0%

3,4,5-trimethoxyphenyl methanesulfonate + acetone (67-64-1) → (3,4,5-trimethoxyphenyl)acetone (16603-18-2)

Guidance literature:

With potassium phosphate; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; In 1,4-dioxane; tert-butyl alcohol; at 90 ℃; Inert atmosphere; Glovebox;

DOI:10.1002/anie.201303305

upstream raw materials:

1-(3,4,5-trimethoxyphenyl)-2-nitro-1-propene

1,2,3-trimethoxy-5-(2-nitro-propenyl)benzene

1,2,3-Trimethoxy-5-[2-methylsulfanyl-2-(toluene-4-sulfonyl)-propyl]-benzene

1-(3,5-dimethoxy-4-hydroxyphenyl)propan-2-one

Refernces

• 1、 Sathish, Manda,Chetna, Jadala,Hari Krishna, Namballa,Shankaraiah, Nagula,Alarifi, Abdullah,Kamal, Ahmed. "Iron-Mediated One-Pot Synthesis of 3,5-Diarylpyridines from β-Nitrostyrenes". . p. 2159 - 2165. Retrieved 2016/03/15.
• 2、 Ackermann, Lutz,Mehta, Vaibhav P.. "Palladium-catalyzed mono-α-arylation of acetone with aryl imidazolylsulfonates". supporting information; experimental part. p. 10230 - 10233. Retrieved 2012/09/22.