4-Cyclohexylmorpholine

Base Information

• Chemical Name: 4-Cyclohexylmorpholine
• CAS No.: 6425-41-8
• Molecular Formula: C10H19NO
• Molecular Weight: 169.267
• Hs Code.: 2934999090
• European Community (EC) Number: 229-195-2
• NSC Number: 151054
• DSSTox Substance ID: DTXSID30214471
• Nikkaji Number: J171.285C
• Wikidata: Q83090320
• Mol file: 6425-41-8.mol

Synonyms:4-Cyclohexylmorpholine;6425-41-8;Morpholine, 4-cyclohexyl-;N-Cyclohexylmorpholine;Cyclohexylmorpholine;N-(1-Cyclohexenyl)morpholine;N-Cyclohexylmorpholine aerosol;MORPHOLINE, 4-CYCLOHEXYL-, (aerosol);EINECS 229-195-2;NSC 151054;BRN 0106846;4-27-00-00034 (Beilstein Handbook Reference);morpholinocyclohexane;Morpholine, (aerosol);4-cyclohexyl-morpholine;SCHEMBL35550;C1(CCCCC1)N2CCOCC2;DTXSID30214471;NSC151054;AKOS006237640;NSC-151054;LS-92668;WLN: T6N DOTJ A- AL6TJ -AEROSOL;A8819;FT-0652288;F71442

Chemical Property of 4-Cyclohexylmorpholine

Chemical Property:

• Vapor Pressure: 0.0399mmHg at 25°C
• Refractive Index: 1.496
• Boiling Point: 239.6 °C at 760 mmHg
• Flash Point: 69.6 °C
• PSA: 12.47000
• Density: 1.003 g/cm³
• LogP: 1.58920
• Storage Temp.: 2-8°C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 169.146664230
• Heavy Atom Count: 12
• Complexity: 126

Purity/Quality:

99.5% ^*data from raw suppliers

4-Cyclohexylmorpholine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)N2CCOCC2

Technology Process of 4-Cyclohexylmorpholine

There total 45 articles about 4-Cyclohexylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + 1-(phenoxymethyl)-4-(trifluoromethyl)benzene (19962-24-4) → N-cyclohexylmorpholine (6425-41-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In m-xylene; at 140 ℃; for 10h; under 7500.75 Torr; Autoclave; Green chemistry;

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + (benzyloxy)benzene (946-80-5) → N-cyclohexylmorpholine (6425-41-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In m-xylene; at 90 ℃; for 6h; under 7500.75 Torr; Autoclave; Green chemistry;

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + phenol (108-95-2,27073-41-2) → N-cyclohexylmorpholine (6425-41-8)

Guidance literature:

With palladium on activated charcoal; hydrogen; at 140 ℃; for 24h; under 15001.5 Torr;

DOI:10.1039/d1gc02790e

upstream raw materials:

morpholine

1-bromocyclohexane

4-Phenylmorpholine

N-cyclohexyl-diethanolamine

Downstream raw materials:

2-[N,N'-bis(ethoxycarbonyl)hydrazino]-1-cyclohexanone

2,6-bis[N,N'-bis(ethoxycarbonyl)hydrazino]-1-cyclohexanone

3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid

Refernces

• 1、 Ueno, Atsushi,Tao, Xin,Daniliuc, Constantin G.,Kehr, Gerald,Erker, Gerhard. "Unusual 1,1-Hydroboration Route to a Reactive Unsaturated Vicinal Frustrated Phosphane/Borane Lewis Pair". . p. 2665 - 2668. Retrieved 2018.
• 2、 Zou, Qizhuang,Liu, Fei,Zhao, Tianxiang,Hu, Xingbang. "Reductive amination of ketones/aldehydes with amines using BH3N(C2H5)3as a reductant". supporting information. p. 8588 - 8591. Retrieved 2021/09/04.
• 3、 Pulido-Díaz, Israel T.,Serrano-Maldonado, Alejandro,López-Suárez, Carlos César,Méndez-Ocampo, Pedro A.,Portales-Martínez, Benjamín,Gutiérrez-Alejandre, Aída,Salas-Martin, Karla P.,Guerrero-Ríos, Itzel. "RhNPs supported onN-functionalized mesoporous silica: effect on catalyst stabilization and catalytic activity". . p. 3289 - 3298. Retrieved 2021/03/16.