19-Nor-17-alpha-pregna-3,5-dien-20-yne-3,17-diol, diacetate

Base Information

• Chemical Name: 19-Nor-17-alpha-pregna-3,5-dien-20-yne-3,17-diol, diacetate
• CAS No.: 2205-78-9
• Molecular Formula: C24H30O4
• Molecular Weight: 382.5
• Mol file: 2205-78-9.mol

Synonyms:19-Nor-17a-pregna-3,5-dien-20-yne-3,17-diol,diacetate (6CI,7CI,8CI);17-Ethynyl-19-norandrosta-3,5-diene-3,17b-diol diacetate;19-Nor-17a-pregna-3,5-dien-20-yne-3,17b-diol diacetate;SC 6091;

Chemical Property of 19-Nor-17-alpha-pregna-3,5-dien-20-yne-3,17-diol, diacetate

Chemical Property:

• Vapor Pressure: 4.33E-10mmHg at 25°C
• Melting Point: 167-169 °C(Solv: methanol (67-56-1))
• Refractive Index: 1.559
• Boiling Point: 499 °C at 760 mmHg
• Flash Point: 246.1 °C
• PSA: 52.60000
• Density: 1.16g/cm³
• LogP: 4.55110
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

(17α)-19-Norpregna-3,5-dien-20-yne-3,17-diol3,17-Diacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Inhibits the development of uterus decidua. Estrogenic activity.

Technology Process of 19-Nor-17-alpha-pregna-3,5-dien-20-yne-3,17-diol, diacetate

There total 12 articles about 19-Nor-17-alpha-pregna-3,5-dien-20-yne-3,17-diol, diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

norethisterone (68-22-4) + acetyl chloride (75-36-5) → 3,17-diacetoxy-19-nor-17βH-pregna-3,5-dien-20-yne (2205-78-9)

Guidance literature:

With pyridine; acetic anhydride; at 20 ℃; for 6h; Industrial scale;

Reference yield:

norethisterone (68-22-4) → 3,17-diacetoxy-19-nor-17βH-pregna-3,5-dien-20-yne (2205-78-9)

Guidance literature:

With acetic anhydride; toluene-4-sulfonic acid;

Reference yield:

octanol (111-87-5) → 3,17-diacetoxy-19-nor-17βH-pregna-3,5-dien-20-yne (2205-78-9)

Guidance literature:

Multi-step reaction with 5 steps

1: ammonium chloride; lithium / tetrahydrofuran; ethanol; ammonia; water

2: aluminum isopropoxide; sodium sulfate / methanol; water; cyclohexanone; toluene

3: 1,4-dioxane; methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ISOPROPYLAMIDE

4: hydrogenchloride / methanol; water

5: acetic anhydride; toluene-4-sulfonic acid

With hydrogenchloride; ammonium chloride; acetic anhydride; aluminum isopropoxide; lithium; toluene-4-sulfonic acid; sodium sulfate; In tetrahydrofuran; 1,4-dioxane; methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol; ISOPROPYLAMIDE; ammonia; water; cyclohexanone; toluene;

upstream raw materials:

norethisterone

acetic anhydride

octanol

3-methoxy-17-hydroxyestra-2,5⁽¹⁰⁾-diene

Downstream raw materials:

19-nor-17βH-pregn-5-en-20-yne-3β,17-diol

17-hydroxy-19-nor-17βH-pregn-5-en-20-yn-3-one

tibolone

norethisterone acetate

Refernces

• 1、 -. "Synthesis of gon-4-enes". . . Retrieved 2008/06/13.