N-Acetoacetyl cresidine

Base Information

• Chemical Name: N-Acetoacetyl cresidine
• CAS No.: 85968-72-5
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.256
• Mol file: 85968-72-5.mol

Synonyms:N-(2-methoxy-5-methyl-phenyl)-3-oxo-butanamide;ACETOACET-P-CRESIDINE;N-Acetoacet Cresidine;butanamide, N-(2-methoxy-5-methylphenyl)-3-oxo-;

Chemical Property of N-Acetoacetyl cresidine

Chemical Property:

• Vapor Pressure: 7.46E-06mmHg at 25°C
• Melting Point: 82 °C(Solv: ethanol (64-17-5))
• Refractive Index: 1.548
• Boiling Point: 376 °C at 760 mmHg
• PKA: 11.26±0.46(Predicted)
• Flash Point: 181.2 °C
• PSA: 55.40000
• Density: 1.146 g/cm³
• LogP: 1.99420

Purity/Quality:

99% ^*data from raw suppliers

N-ACETOACETYL CRESIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Acetoacetyl cresidine

There total 2 articles about N-Acetoacetyl cresidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyleneoxetan-2-one (674-82-8,2130-41-8) + Cresidine (120-71-8) → acetoacetic acid-(2-methoxy-5-methyl-anilide) (85968-72-5)

Guidance literature:

DOI:10.1246/bcsj.36.492

Reference yield:

ethyl acetoacetate (141-97-9) + Cresidine (120-71-8) → acetoacetic acid-(2-methoxy-5-methyl-anilide) (85968-72-5)

Guidance literature:

With boiling solvent naphtha;

Reference yield:

acetoacetic acid-(2-methoxy-5-methyl-anilide) (85968-72-5) + 3-amino-4-hydroxybenzenesulfonamide (98-32-8) → (2-Hydroxy-5-sulfamoyl-phenylazo)-acetoacet-2-methoxy-5-methyl-anilid (95365-36-9)

Guidance literature:

Multistep reaction; (i) (diazotization), (ii) /BRN= 2733307/, Na₂CO₃, NaOH;

DOI:10.1246/bcsj.36.492

upstream raw materials:

ethyl acetoacetate

Cresidine

4-methyleneoxetan-2-one

Downstream raw materials:

(2-Hydroxy-5-sulfamoyl-phenylazo)-acetoacet-2-methoxy-5-methyl-anilid

Refernces