1-Bromo-2-methoxyethane

Base Information

• Chemical Name: 1-Bromo-2-methoxyethane
• CAS No.: 6482-24-2
• Molecular Formula: C3H7 Br O
• Molecular Weight: 138.992
• Hs Code.: 29091990
• European Community (EC) Number: 229-339-4
• NSC Number: 81806
• UNII: QMC9NTS6GR
• DSSTox Substance ID: DTXSID0064385
• Nikkaji Number: J208.123G
• Wikidata: Q72446167
• Mol file: 6482-24-2.mol

Synonyms:1-Bromo-2-methoxyethane;2-Bromoethyl methyl ether;6482-24-2;Ethane, 1-bromo-2-methoxy-;2-Methoxyethyl bromide;1-bromo-2-methoxy-ethane;Amberlyst 15;9037-24-5;Ether, 2-bromoethyl methyl;2-bromoethylmethylether;2-bromo-1-methoxyethane;Methoxyethyl bromide;Amberlyst(R)15;2-bromoethylmethyl ether;QMC9NTS6GR;2-methoxy-1-bromoethane;EINECS 229-339-4;MFCD00000236;NSC 81806;NSC-81806;2-bromethylmethylether;bromoethyl methyl ether;Methoxyethylbromide;bromoethylmethylether;2-methoxybromoethane;2-methoxyethylbromide;bromoethyl methylether;bromoethylmethyl ether;methoxy ethyl bromide;BrCH2CH2OMe;bromo-2-methoxyethane;2-methoxyl-bromoethane;1-bromo-2-methoxyethan;2 -methoxyethyl bromide;2-bromoethyl methylether;2-bromoethyl-methylether;2-bromoethylmethyl-ether;2-methoxy ethyl bromide;2-methoxy-ethyl bromide;UNII-QMC9NTS6GR;2- Methoxyethyl bromide;2-bromethyl methyl ether;2-(methoxy)ethyl bromide;2-Bromoethyl-methyl ether;1-bromo -2-methoxyethane;1-bromo-2-methoxy ethane;(2-bromoethyl)-methylether;(2-bromoethyl)methyl ether;2-bromoethanol methyl ether;Br(CH2)2OCH3;SCHEMBL5316;(2-bromoethyl) methyl ether;(2-bromoethyl)-methyl ether;beta-bromo-ethyl methyl ether;1-bromo-2-(methyloxy)ethane;(2-METHOXY)BROMOETHANE;DTXSID0064385;YZUPZGFPHUVJKC-UHFFFAOYSA-;.BETA.-METHOXYETHYL BROMIDE;BCP24711;NSC81806;STR05916;STL183830;AKOS000121852;BP-21286;A8836;B1242;CS-0015336;FT-0602321;EN300-28738;P19803;J-504400;F2190-0183

Chemical Property of 1-Bromo-2-methoxyethane

Chemical Property:

• Appearance/Colour: clear colorless to yellow liquid
• Vapor Pressure: 32.5mmHg at 25°C
• Refractive Index: n20/D 1.447(lit.)
• Boiling Point: 106.8 °C at 760 mmHg
• Flash Point: 28.3 °C
• PSA: 9.23000
• Density: 1.424 g/cm³
• LogP: 1.02770
• Storage Temp.: Refrigerator
• Solubility.: water: soluble14.4g/L at 25°C
• Water Solubility.: Soluble in water.14,4 g/L at 25°C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 137.96803
• Heavy Atom Count: 5
• Complexity: 16.4

Purity/Quality:

99%min ^*data from raw suppliers

2-Bromoethyl methyl ether ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,F,Xn
• Hazard Codes: Xi,F,Xn
• Statements: 10-36/37/38-22
• Safety Statements: 16-26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Halogenated Ethers
• Canonical SMILES: COCCBr
• Uses: 1-Bromo-2-methoxyethane has been used as starting reagent in the synthesis of 1-bromo-4-(2-methoxyethoxy)benzene and 1-bromo-4-[(2-methoxyethoxy)methyl]benzene. 2-Bromoethyl methyl ether has been used as starting reagent in the synthesis of 1-bromo-4-(2-methoxyethoxy)benzene and 1-bromo-4-[(2-methoxyethoxy)methyl]benzene.

Technology Process of 1-Bromo-2-methoxyethane

There total 13 articles about 1-Bromo-2-methoxyethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-methoxy-ethanol (109-86-4,95507-80-5) → 2-Bromoethyl methyl ether (6482-24-2)

Guidance literature:

With sulfurous dibromide; N,N-dimethyl acetamide; In dichloromethane; at 0 ℃; for 7h; Product distribution / selectivity; Heating / reflux;

Reference yield: 67.0%

methanol (67-56-1) → Methyl 3-bromopropionate (3395-91-3) + methyl 3-methoxypropionate (3852-09-3) + ethylene dibromide (106-93-4) + 2-Bromoethyl methyl ether (6482-24-2)

Guidance literature:

With bromine; at -80 ℃; temperature up to 30 deg C;

DOI:10.1016/S0040-4039(00)92190-7

Reference yield:

dimethyl sulfate (77-78-1) + 2-bromoethanol (540-51-2) → 2-Bromoethyl methyl ether (6482-24-2)

Guidance literature:

With calcium carbonate; at 120 - 150 ℃;

DOI:10.1021/ja01218a043

upstream raw materials:

2-methoxy-ethanol

2-iodo-1-methoxyethane

dimethyl sulfate

2-bromoethanol

Downstream raw materials:

β-Methoxyethyl-methyl-malonsaeurediethylester

(2-Methoxy-ethyl)-propyl-malonsaeure-diethylester

Dibenzyl-[(S)-3-(tert-butyl-dimethyl-silanyloxy)-1-(2-methoxy-ethoxymethyl)-propyl]-amine

ethene

Refernces

• 1、 -. "ELECTROSPUN POLYMER NANOFIBERS WITH SURFACE ACTIVE QUATERNARY AMMONIUM SALT ANTIMICROBIALS". Paragraph 0027. . Retrieved 2014/08/19.
• 2、 Bini, Riccardo,Marchetti, Fabio,Pampaloni, Guido,Zacchini, Stefano. "Further insights into the chemistry of niobium and tantalum pentahalides with 1,2-dialkoxyalkanes: Synthesis of bromo- and iodoalkoxides, spectroscopic and computational studies". experimental part. p. 1412 - 1419. Retrieved 2011/06/22.