1-N-BOC-4-(2-FLUOROPHENYL)-4-HYDROXYPIPERIDINE

Base Information

• Chemical Name: 1-N-BOC-4-(2-FLUOROPHENYL)-4-HYDROXYPIPERIDINE
• CAS No.: 403806-35-9
• Molecular Formula: C16H22FNO3
• Molecular Weight: 295.354
• Hs Code.: 2933399090
• Mol file: 403806-35-9.mol

Synonyms:4-(2-fluorophenyl)-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester;1-N-BOC-4-(2-FLUOROPHENYL)-4-HYDROXYPIPERIDINE;

Chemical Property of 1-N-BOC-4-(2-FLUOROPHENYL)-4-HYDROXYPIPERIDINE

Chemical Property:

• Boiling Point: 404.0±45.0 °C(Predicted)
• PKA: 13.52±0.20(Predicted)
• PSA: 49.77000
• Density: 1.188±0.06 g/cm3(Predicted)
• LogP: 2.98210

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl 4-(2-fluorophenyl)-4-hydroxy-1-piperidinecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-N-BOC-4-(2-FLUOROPHENYL)-4-HYDROXYPIPERIDINE

There total 3 articles about 1-N-BOC-4-(2-FLUOROPHENYL)-4-HYDROXYPIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-Fluoro-2-iodobenzene (348-52-7) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 4-(2-fluoro-phenyl)-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (403806-35-9)

Guidance literature:

1-Fluoro-2-iodobenzene; With isopropylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 0.25h;

N-tert-butyloxycarbonylpiperidin-4-one; In tetrahydrofuran; at 20 ℃;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield: 65.0%

o-fluorobromobenzene (1072-85-1) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 4-(2-fluoro-phenyl)-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (403806-35-9)

Guidance literature:

o-fluorobromobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -70 ℃; for 0.5h; Inert atmosphere;

N-tert-butyloxycarbonylpiperidin-4-one; In tetrahydrofuran; hexane; for 0.5h; Inert atmosphere;

Reference yield: 61.0%

→ 4-(2-fluoro-phenyl)-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (403806-35-9)

Guidance literature:

upstream raw materials:

o-fluorobromobenzene

N-tert-butyloxycarbonylpiperidin-4-one

1-Fluoro-2-iodobenzene

Downstream raw materials:

4-(2-fluoro-phenyl)-piperidin-4-ol hydrochloride

4-fluoro-4-(2-fluorophenyl)piperidine-1-sulfonamide

4-fluoro-4-(2-fluorophenyl)piperidine hydrochloride

4-(fluorophenyl)-4-hydroxypiperidine

Refernces

• 1、 -. "Hydroxylated sulfamides exhibiting neuroprotective action and their method of use". Page/Page column 35. . Retrieved 2014/02/15.
• 2、 -. "Pyrrolopyrimidine A2b selective antagonist compounds, their synthesis and use". Page 25. . Retrieved 2010/02/06.