Technology Process of Butanoic acid, 2-[[(acetylamino)acetyl]amino]-3-(phenylseleno)-,
phenylmethyl ester, (2R,3S)-
There total 5 articles about Butanoic acid, 2-[[(acetylamino)acetyl]amino]-3-(phenylseleno)-,
phenylmethyl ester, (2R,3S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2R,3S)-2-tert-butoxycarbonylamino-3-phenylselanyl-butyric acid benzyl ester;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 1h;
N-acetylglycine;
With
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
acetonitrile;
for 1h;
Further stages.;
DOI:10.1039/b304945k
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 70 percent Turnov. / pyridine / 48 h / 0 °C
2: 67 percent / KOH / dimethylformamide
3: TFA / CH2Cl2 / 1 h / 20 °C
4: 0.052 g / Bop; diisopropylethylamine / acetonitrile / 1 h
With
pyridine; potassium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol025629g
- Guidance literature:
-
Multi-step reaction with 2 steps
1: TFA / CH2Cl2 / 1 h / 20 °C
2: 0.052 g / Bop; diisopropylethylamine / acetonitrile / 1 h
With
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
dichloromethane; acetonitrile;
DOI:10.1021/ol025629g
