N-Methyl-N-acetyl-2-phenylethanamine

Base Information

• Chemical Name: N-Methyl-N-acetyl-2-phenylethanamine
• CAS No.: 50893-11-3
• Molecular Formula: C11H15NO
• Molecular Weight: 177.246
• Mol file: 50893-11-3.mol

Synonyms:N-Methyl-N-phenaethyl-acetamid;N-methyl-N-phenethyl-acetamide;N-Methyl-N-phenethylacetamid;N-Acetyl-N-methyl-2-phenylethylamin;

Chemical Property of N-Methyl-N-acetyl-2-phenylethanamine

Chemical Property:

• Melting Point: 38-39 °C
• Boiling Point: 100 - 103 °C (0.01 mmHg)
• PKA: -0.50±0.70(Predicted)
• PSA: 20.31000
• Density: 1.006±0.06 g/cm3(Predicted)
• LogP: 1.70740

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Methyl-N-acetyl-2-phenylethanamine

There total 6 articles about N-Methyl-N-acetyl-2-phenylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

acetamide (60-35-5) + N-Methyl-N-phenethylamine (589-08-2) → N-methyl-N-phenyethylacetamide (50893-11-3)

Guidance literature:

With manganese(II) chloride tetrahydrate; at 150 ℃; for 10h; Sealed tube; Microwave irradiation; Inert atmosphere;

DOI:10.1055/s-0037-1610267

Reference yield: 80.0%

acetic anhydride (108-24-7) + N,N-dimethylphenethylamine (1126-71-2) → N-methyl-N-phenyethylacetamide (50893-11-3)

Guidance literature:

With tert.-butylhydroperoxide; water; In acetonitrile; at 70 ℃; for 0.5h;

DOI:10.1002/cctc.201801858

Reference yield:

N-(2-phenylethyl)formamide (23069-99-0) → N-methyl-N-phenyethylacetamide (50893-11-3)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄; diethyl ether

With lithium aluminium tetrahydride; diethyl ether;

DOI:10.1021/ja01550a042

upstream raw materials:

acetic anhydride

N-Methyl-N-phenethylamine

N-(2-phenylethyl)formamide

1-phenyl-2-bromoethane

Downstream raw materials:

γ--buttersaeure

2-Methyl-1-methylen-1,2,3,4-tetrahydroisochinolin

γ--butansaeure

β--propionsaeure

Refernces

• 1、 Ma, Juan,Zhang, Jingyu,Gong, Hang. "Mn(II)-Catalyzed N -Acylation of Amines". . p. 693 - 703. Retrieved 2019/01/23.
• 2、 Ma, Juan,Zhang, Feng,Zhang, Jingyu,Gong, Hang. "Cobalt(II)-Catalyzed N-Acylation of Amines through a Transamidation Reaction". . p. 4940 - 4948. Retrieved 2018/09/25.