Stilbamidine

Base Information

• Chemical Name: Stilbamidine
• CAS No.: 122-06-5
• Molecular Formula: C16H16 N4
• Molecular Weight: 264.33
• European Community (EC) Number: 204-519-5
• UNII: ST31IIO5EW
• Nikkaji Number: J297.772I
• Wikidata: Q27289385
• ChEMBL ID: CHEMBL142304
• Mol file: 122-06-5.mol

Synonyms:4,4'-stilbenedicarboxamidine;stilbamidine;stilbamidine dihydrochloride;stilbamidine isethionate;stilbamidine, isethionate (2:1)

Chemical Property of Stilbamidine

Chemical Property:

• Vapor Pressure: 1.62E-08mmHg at 25°C
• Boiling Point: 456.4°Cat760mmHg
• Flash Point: 229.8°C
• Density: 1.19g/cm³
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 264.137496527
• Heavy Atom Count: 20
• Complexity: 336

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C=CC2=CC=C(C=C2)C(=N)N)C(=N)N
• Isomeric SMILES: C1=CC(=CC=C1/C=C/C2=CC=C(C=C2)C(=N)N)C(=N)N

Technology Process of Stilbamidine

There total 165 articles about Stilbamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(4-methoxylphenyl)-2-propen-1-ol (51410-44-7) → 4-Methoxypropiophenone (121-97-1)

Guidance literature:

With tris(acetonitrile)pentamethylcyclopentadienylruthenium(II) hexafluorophosphate; potassium carbonate; In acetonitrile; for 1h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2008.09.095

Reference yield: 99.0%

triethyl borane (97-94-9) + 4-methoxy-N-phenyl-N-tosylbenzamide → 4-Methoxypropiophenone (121-97-1)

Guidance literature:

With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate; In tetrahydrofuran; tert-butyl methyl ether; at 20 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.3390/molecules23092412

Reference yield: 98.0%

triethyl borane (97-94-9) + N-methyl-N-tosyl-p-methoxybenzamide (1445317-61-2) → 4-Methoxypropiophenone (121-97-1)

Guidance literature:

With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate; In tetrahydrofuran; tert-butyl methyl ether; at 20 ℃; for 24h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere; Schlenk technique;

DOI:10.3390/molecules23092412

upstream raw materials:

4-methoxyphenylacetamide

ethylmagnesium bromide

1-(4-methoxyphenyl)prop-2-en-1-one

4-methoxy-N,N-diethylbenzamide

Downstream raw materials:

cis-stilbene-4,4’-dicarboxylic acid

Refernces

• 1、 Baeyens, Jan,Li, Peifeng,Ouyang, Yixuan,Sarina, Sarina,Su, Haijia,Xiao, Gang,Zhao, Yilin,Zhu, Huai-Yong. "Non-plasmonic Ni nanoparticles catalyzed visible light selective hydrogenolysis of aryl ethers in lignin under mild conditions". supporting information. p. 7780 - 7789. Retrieved 2021/10/12.
• 2、 Upadhyay, Rahul,Kumar, Shashi,Maurya, Sushil K.. "V2O5@TiO2 Catalyzed Green and Selective Oxidation of Alcohols, Alkylbenzenes and Styrenes to Carbonyls". . p. 3594 - 3600. Retrieved 2021/07/02.