1H-Pyrazole, 5-methyl-3-phenyl-

Base Information

• Chemical Name: 1H-Pyrazole, 5-methyl-3-phenyl-
• CAS No.: 56426-41-6
• Molecular Formula: C10H10N2
• Molecular Weight: 158.203
• Mol file: 56426-41-6.mol

Synonyms:

Chemical Property of 1H-Pyrazole, 5-methyl-3-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole, 5-methyl-3-phenyl-

There total 47 articles about 1H-Pyrazole, 5-methyl-3-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-phenylbutan-1,3-dione (93-91-4) → 3-methyl-5-phenylpyrazole (56426-41-6)

Guidance literature:

With carbazic acid; at 90 ℃; for 3h; Green chemistry;

DOI:10.1016/j.tetlet.2012.12.106

Reference yield: 95.0%

(E)-benzalacetone (1896-62-4) → 3-methyl-5-phenylpyrazole (56426-41-6)

Guidance literature:

With hydrazine hydrochloride; iodine; In ethanol; for 1h; Heating;

Reference yield: 95.0%

trans-4-phenyl-3-buten-2-one tosylhydrazone (53941-18-7) → 3-methyl-5-phenylpyrazole (56426-41-6)

Guidance literature:

With potassium carbonate; N,N-dimethyl-formamide; at 130 ℃; for 0.0166667h; microwave irradiation;

DOI:10.3390/12071482

upstream raw materials:

3-methyl-5-phenylisoxazole

3-methyl-5-phenyl-4,5-dihydro-1H-pyrazole

mercury(II) diacetate

acetic acid

Downstream raw materials:

1,5-dimethyl-3-phenyl-1H-pyrazole

1,3-dimethyl-5-phenyl-1H-pyrazole

1-ethyl-5-methyl-3-phenyl-1H-pyrazole

1-Propionyl-5-methyl-3-phenyl-pyrazol

Refernces

• 1、 Voitekhovich,Gaponik,Kliaus,Ivashkevich. "Thermal recyclization of 5-R-2-isopropenyltetrazoles into 5-R-3-methylpyrazoles [2]". . p. 1422 - 1423. Retrieved 2002.
• 2、 Fu, Ying,Gao, Shuang,Jia, Ling,Ye, Fei,Zhang, Yuan-Yuan,Zhao, Li-Xia. "Fragmenlt Recombination Design, Synthesis, and Safener Activity of Novel Ester-Substituted Pyrazole Derivatives". . p. 8366 - 8379. Retrieved 2021/08/20.
• 3、 -. "Pyrazole derivative compound, and preparation method and application thereof". Paragraph 0035-0036; 0055-0056. . Retrieved 2020/04/06.