Naloxyindole

Base Information

• Chemical Name: Naloxyindole
• CAS No.: 126580-45-8
• Molecular Formula: C₂₅H₂₄N₂O₃
• Molecular Weight: 400.477
• Mol file: 126580-45-8.mol

Synonyms:4,8-Methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol,5,6,7,8,14,14b-hexahydro-7-(2-propenyl)-, [8R-(4bS*,8a,8ab,14bb)]-; N-Allyl-N-demethyloxymorphindole; Naloxyindole

Chemical Property of Naloxyindole

Chemical Property:

• PSA: 68.72000
• LogP: 3.28650

Purity/Quality:

NALOXYINDOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Naloxyindole

There total 2 articles about Naloxyindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

phenylhydrazine hydrochloride (59-88-1) + naloxone hydrochloride (357-08-4) → SYK-706 (126580-45-8)

Guidance literature:

With hydrogenchloride; In methanol; for 5h; Heating;

DOI:10.1021/jm00168a028

Reference yield:

Naloxone (465-65-6) + phenylhydrazine hydrochloride (59-88-1) → SYK-706 (126580-45-8)

Guidance literature:

With acetic acid; Reflux;

DOI:10.1021/acschemneuro.9b00067

upstream raw materials:

phenylhydrazine hydrochloride

naloxone hydrochloride

Naloxone

Refernces

• 1、 Portoghese,Sultana,Takemori. "Design of peptidomimetic δ opioid receptor antagonists using the message-address concept". . p. 1714 - 1720. Retrieved 2007/10/02.