2-[(4-chlorophenyl)sulfonyl]benzene-1,4-diol

Base Information

• Chemical Name: 2-[(4-chlorophenyl)sulfonyl]benzene-1,4-diol
• CAS No.: 6269-31-4
• Molecular Formula: C12H9ClO4S
• Molecular Weight: 284.72
• Mol file: 6269-31-4.mol

Synonyms:

Chemical Property of 2-[(4-chlorophenyl)sulfonyl]benzene-1,4-diol

Chemical Property:

• Vapor Pressure: 6.36E-12mmHg at 25°C
• Boiling Point: 531.7°Cat760mmHg
• Flash Point: 275.4°C
• Density: 1.525g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(4-chlorophenyl)sulfonyl]benzene-1,4-diol

There total 8 articles about 2-[(4-chlorophenyl)sulfonyl]benzene-1,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

sodium p-chlorobenzenesulphinate (14752-66-0) + hydroquinone (123-31-9,8027-02-9) → 2-((4-chlorophenyl)sulfonyl)benzene-1,4-diol (6269-31-4)

Guidance literature:

With laccase from Trametes versicolor; oxygen; In aq. phosphate buffer; at 20 ℃; for 19h; pH=5; Green chemistry; Enzymatic reaction;

DOI:10.1016/j.tetlet.2016.11.119

Reference yield: 83.8%

1-(4-hydroxyphenyl)piperazine (56621-48-8) + 4-chlorobenzenesulfinic acid (100-03-8) → 2-((4-chlorophenyl)sulfonyl)benzene-1,4-diol (6269-31-4)

Guidance literature:

1-(4-hydroxyphenyl)piperazine; In aq. phosphate buffer; pH=2; Electrolysis;

4-chlorobenzenesulfinic acid; In aq. phosphate buffer; for 0.166667h;

DOI:10.1016/j.electacta.2014.09.122

Reference yield: 80.0%

sodium p-chlorobenzenesulphinate (14752-66-0) + p-benzoquinone (106-51-4) → 2-((4-chlorophenyl)sulfonyl)benzene-1,4-diol (6269-31-4)

Guidance literature:

With ammonium iodide; In methanol; at 40 ℃; for 2h; Schlenk technique;

DOI:10.1016/j.tet.2017.10.022

upstream raw materials:

4-chlorobenzenesulfinic acid

p-benzoquinone

4-chlorobenzenesulfonyl chloride

hydroquinone

Refernces

• 1、 Sun, Xue,Zhang, Fanjun,Yan, Kelu,Feng, Wenfeng,Sun, Xuejun,Yang, Jianjing,Wen, Jiangwei. "Electrochemical-In-Situ-Oxidative Sulfonylation of Phenols with Sulfinic Acids as an Access to Sulfonylated Hydroquinones". supporting information. p. 3485 - 3490. Retrieved 2021/06/17.
• 2、 Yuan, Jin-Wei,Liu, Shuai-Nan,Qu, Ling-Bo. "Ammonium iodide-promoted unprecedented arylsulfonylation of quinone with sodium arylsulfinates". . p. 6763 - 6772. Retrieved 2017/10/26.