Epibuphanisine

Base Information

• Chemical Name: Epibuphanisine
• CAS No.: 468-22-4
• Molecular Formula: C17H19NO3
• Molecular Weight: 285.3377
• Mol file: 468-22-4.mol

Synonyms:Buphanisin;

Chemical Property of Epibuphanisine

Chemical Property:

• Vapor Pressure: 3.64E-07mmHg at 25°C
• Boiling Point: 417.1°Cat760mmHg
• Flash Point: 127°C
• PSA: 30.93000
• Density: 1.33g/cm³
• LogP: 2.15380

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Epibuphanisine

There total 20 articles about Epibuphanisine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

Crinine (510-67-8,510-69-0,546-05-4,7679-52-9,7679-55-2,25375-48-8) + diazomethyl-trimethyl-silane (18107-18-1) → buphanisine (468-22-4)

Guidance literature:

With tetrafluoroboric acid; In diethyl ether; dichloromethane; for 36h;

Reference yield: 62.0%

crinine (909263-42-9) + diazomethyl-trimethyl-silane (18107-18-1) → buphanisine (468-22-4,6835-79-6,111958-06-6,124093-57-8)

Guidance literature:

With tetrafluoroboric acid; In dichloromethane; for 36h;

DOI:10.1039/c7sc02112g

Reference yield: 40.0%

C16H16ClNO2 + sodium methylate (124-41-4) → buphanisine (468-22-4) + epibuphanisine

Guidance literature:

for 4h; Reflux;

DOI:10.1039/c7sc01859b

upstream raw materials:

(+/-)-oxo-crinine

crinine

diazomethyl-trimethyl-silane

(3aS*,6R*,7aR*)-3a-<3,4-(methylenedioxy)phenyl>-6-methoxy-2,3,3a,6,7,7a-hexahydro-1H-indole

Refernces

• 1、 Zuo, Xiao-Dong,Guo, Shu-Min,Yang, Rui,Xie, Jian-Hua,Zhou, Qi-Lin. "Bioinspired enantioselective synthesis of crinine-type alkaloids: Via iridium-catalyzed asymmetric hydrogenation of enones". . p. 6202 - 6206. Retrieved 2017/08/29.
• 2、 -. "A through intra-molecular to aromatization and efficient synthesis of the wenshu blue alkali and its analogue (by machine translation)". . . Retrieved 2017/08/28.