rac 1-PalMitoyl-2-chloropropanediol

Base Information

• Chemical Name: rac 1-PalMitoyl-2-chloropropanediol
• CAS No.: 63326-63-6
• Molecular Formula: C19H37ClO3
• Molecular Weight: 348.94800
• Mol file: 63326-63-6.mol

Synonyms:[(2S)-2-chloro-3-hydroxypropyl] hexadecanoate;

Chemical Property of rac 1-PalMitoyl-2-chloropropanediol

Chemical Property:

• Melting Point: 35 - 36°C
• PSA: 46.53000
• LogP: 5.61060
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

rac 1-Palmitoyl-2-chloropropanediol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A halopropanediol esterified with fatty acid. ension culture. A halopropanediol esterified with fatty acid. Analogs of monoacylglycerols or monoalkylglycerols had a strong inhibitory activity on the proliferation of Ehrlich ascites carcinoma (EAC) cells in suspension culture.

Technology Process of rac 1-PalMitoyl-2-chloropropanediol

There total 4 articles about rac 1-PalMitoyl-2-chloropropanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-propane-1,3-diol (497-04-1) + 1-hexadecylcarboxylic acid (57-10-3) → 2-MCPD 1-palmitate (63326-63-6)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.jafc.9b01083

Reference yield:

2-chloro-propane-1,3-diol (497-04-1) + n-hexadecanoyl chloride (112-67-4) → 2-MCPD 1-palmitate (63326-63-6)

Guidance literature:

With pyridine; In diethyl ether;

Reference yield:

Hexadecanoic acid 2-chloro-3-trityloxy-propyl ester (63359-72-8) → 2-MCPD 1-palmitate (63326-63-6)

Guidance literature:

With boric acid; silica gel;

upstream raw materials:

Hexadecanoic acid 2-chloro-3-trityloxy-propyl ester

2-chloro-propane-1,3-diol

n-hexadecanoyl chloride

1-palmitoyl-3-O-trityl-rac-glycerol

Refernces