4-methoxy-N-(4-nitrophenyl)benzamide

Base Information

• Chemical Name: 4-methoxy-N-(4-nitrophenyl)benzamide
• CAS No.: 7464-52-0
• Molecular Formula: C14H12 N2 O4
• Molecular Weight: 272.26
• Mol file: 7464-52-0.mol

Synonyms:p-Anisanilide,4'-nitro- (6CI,7CI,8CI); 4-Methoxy-4'-nitrobenzanilide;N-(4-Nitrophenyl)-4-methoxybenzamide; NSC 404056

Chemical Property of 4-methoxy-N-(4-nitrophenyl)benzamide

Chemical Property:

• Vapor Pressure: 6.8E-06mmHg at 25°C
• Boiling Point: 377.3°Cat760mmHg
• Flash Point: 182°C
• Density: 1.333g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-methoxy-N-(4-nitrophenyl)benzamide

There total 13 articles about 4-methoxy-N-(4-nitrophenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-methoxyphenylacetamide (3424-93-9) + nitrobenzene (98-95-3,26969-40-4) → 4-Methoxy-N-(4-nitrophenyl)benzamide (7464-52-0) + trans-azoxybenzene (20972-43-4,21650-65-7,495-48-7,55599-32-1)

Guidance literature:

With tetramethyl ammoniumhydroxide; at 70 ℃; for 4h; under 40 Torr;

DOI:10.1021/jo00076a059

Reference yield: 91.0%

4-methoxy-benzaldehyde (123-11-5) + 4-nitro-aniline (100-01-6,104810-17-5) → 4-Methoxy-N-(4-nitrophenyl)benzamide (7464-52-0)

Guidance literature:

4-nitro-aniline; With tert.-butylnitrite; trimethylsilylazide; In tetrahydrofuran; at 0 ℃;

4-methoxy-benzaldehyde; With 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; sodium t-butanolate; In tetrahydrofuran; at -25 ℃;

DOI:10.1039/c3cc40452h

Reference yield: 83.0%

4-nitro-aniline (100-01-6,104810-17-5) + 4-methoxybenzoic acid (100-09-4) → 4-Methoxy-N-(4-nitrophenyl)benzamide (7464-52-0)

Guidance literature:

With trifluoromethylsulfonic anhydride; polymer-supported triphenylphosphine oxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

DOI:10.1039/b406770c

upstream raw materials:

4-methoxy-benzoyl chloride

4-nitro-aniline

4-Methoxy-N-phenyl-benzimidoyl chloride

4-methoxyphenylacetamide

Downstream raw materials:

N?(4?aminophenyl)?4?methoxybenzamide

4-methoxy-N-(4-nitrophenyl)benzothioamide

(Z)-N-(1-(4-methoxyphenyl)-3-(trimethylsilyl)prop-2-ynylidene)-4-nitroaniline

Refernces

• 1、 -. "COMPOUNDS FOR TREATING TUBERCULOSIS". Paragraph 0095; 00115; 00123. . Retrieved 2018/09/18.
• 2、 Vinayak, Botla,Chandrasekharam, Malapaka. "Copper-Catalyzed Direct Nitration on Aryl C-H Bonds by Concomitant Azidation-Oxidation with TMS Azide and TBHP under Aerobic Conditions". supporting information. p. 3528 - 3531. Retrieved 2017/07/17.