Clozapine EP IMpurity D

Base Information

• Chemical Name: Clozapine EP IMpurity D
• CAS No.: 65514-71-8
• Molecular Formula: C18H21ClN4O
• Molecular Weight: 344.844
• Mol file: 65514-71-8.mol

Synonyms:Piperazine,1-[2-[(2-amino-4-chlorophenyl)amino]benzoyl]-4-methyl;

Chemical Property of Clozapine EP IMpurity D

Chemical Property:

• Vapor Pressure: 1.21E-10mmHg at 25°C
• Melting Point: >103°C (dec.)
• Boiling Point: 513.2oC at 760 mmHg
• PKA: 6.68±0.10(Predicted)
• Flash Point: 264.1oC
• PSA: 61.60000
• Density: 1.297g/cm3
• LogP: 3.58340
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

[2-[(2-Amino-4-chlorophenyl)amino]phenyl](4-methyl-1-piperazinyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Clozapine EP IMpurity D is used in the synthesis of substituted dibenzodiazepines. Also an impurity in the synthesis of Clozepine (C587500), an antipsychotic.

Technology Process of Clozapine EP IMpurity D

There total 1 articles about Clozapine EP IMpurity D which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-methyl-piperazine (109-01-3) + 2-Iodobenzoic acid (88-67-5) + 4-Chloro-2-nitroaniline (89-63-4) → 2-amino-4-chlorodiphenylamine-2'-carboxylic acid (4''-methyl)piperazide (65514-71-8)

Guidance literature:

2-Iodobenzoic acid; 4-Chloro-2-nitroaniline; With copper(l) iodide; potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 2h; Inert atmosphere;

1-methyl-piperazine; With oxalyl dichloride; triethylamine; In dichloromethane; at 0 ℃; for 1h;

With acetic acid; zinc; at 0 ℃; for 0.333333h;

Reference yield: 41.0%

2-amino-4-chlorodiphenylamine-2'-carboxylic acid (4''-methyl)piperazide (65514-71-8) → clozaril (5786-21-0)

Guidance literature:

2-amino-4-chlorodiphenylamine-2'-carboxylic acid (4''-methyl)piperazide; With N,N-dimethyl-aniline; trichlorophosphate; for 3h; Heating / reflux;

With ammonia; In water;

upstream raw materials:

1-methyl-piperazine

2-Iodobenzoic acid

4-Chloro-2-nitroaniline

Downstream raw materials:

clozaril

Refernces