1,1,1-Trimethoxy-2-chloroethane

Base Information

• Chemical Name: 1,1,1-Trimethoxy-2-chloroethane
• CAS No.: 74974-54-2
• Molecular Formula: C5H11ClO3
• Molecular Weight: 154.594
• Hs Code.: 2909199090
• Mol file: 74974-54-2.mol

Synonyms:1-Chloro-2,2,2-trimethoxyethane;2-Chloro-1,1,1-trimethoxyethane;Trimethyl (chloromethyl)orthoformate;Trimethyl orthochloroacetate;

Chemical Property of 1,1,1-Trimethoxy-2-chloroethane

Chemical Property:

• Vapor Pressure: 6.77mmHg at 25°C
• Refractive Index: n20/D 1.425(lit.)
• Boiling Point: 143.215 °C at 760 mmHg
• Flash Point: 40.85 °C
• PSA: 27.69000
• Density: 1.092 g/cm³
• LogP: 0.81820
• Storage Temp.: 2-8°C

Purity/Quality:

2-Chloro-1,1,1-trimethoxyethane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 10
• Safety Statements: 16-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Chloro-1,1,1-trimethoxyethane may be used for the synthesis of chlorotriazolinone, an NK1 antagonist and 2-chloromethyl-7-[3-(trifluoromethyl)pyridin-2-yl]-3H-quinazolin-4-one.

Technology Process of 1,1,1-Trimethoxy-2-chloroethane

There total 5 articles about 1,1,1-Trimethoxy-2-chloroethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.1%

methyl chloroacetate (96-34-4) + trimethyl orthoformate (149-73-5) → 2-chloro-1,1,1-trimethoxyethane (74974-54-2)

Guidance literature:

With sulfuric acid; In methanol; at -10 - 45 ℃; for 2h; Concentration; Temperature;

Reference yield: 90.0%

→ 2-chloro-1,1,1-trimethoxyethane (74974-54-2)

Guidance literature:

With boron trifluoride; In Hexadecane; at 110 ℃; for 6h; Autoclave;

Reference yield: 76.0%

Trimethyl orthoacetate (1445-45-0) → 2-chloro-1,1,1-trimethoxyethane (74974-54-2)

Guidance literature:

With sodium methylate; chlorine; at 15 ℃; for 4h;

upstream raw materials:

Trimethyl orthoacetate

methanol

1,2-dichloro-2-fluoroethene

methyl 2-chloroacetimidate hydrochloride

Downstream raw materials:

2-(chloromethyl)-4-nitrobenzoxazole

2-(chloromethyl)-5-(4-t-butylphenyl)-1,3,4-oxadiazole

2-(chloromethyl)-5-phenyl-1,3,4-oxadiazole

methyl (4E)-6-(2-O-tert-butyldimethylsilyloxy-6-methoxyphenyl)-2-chloro-4-methylhex-4-enoate

Refernces

• 1、 -. "2-chlorine-1,1,1-trimethoxyethane preparing method". Paragraph 0016; 0017. . Retrieved 2016/11/28.
• 2、 -. "Process for the production of 2-Chloro-1,1,1-trialkoxyethane". Page 3. . Retrieved 2008/06/13.