dl-Laudanosoline hydrobromide

Base Information

• Chemical Name: dl-Laudanosoline hydrobromide
• CAS No.: 84030-13-7
• Molecular Formula: C17H19NO4
• Molecular Weight: 382.254
• European Community (EC) Number: 281-783-8
• ChEMBL ID: CHEMBL2165575
• NSC Number: 99800
• Mol file: 84030-13-7.mol

Synonyms:laudanosoline;laudanosoline hydrobromide

Chemical Property of dl-Laudanosoline hydrobromide

Chemical Property:

• Vapor Pressure: 1.28E-12mmHg at 25°C
• Boiling Point: 548°C at 760 mmHg
• Flash Point: 323°C
• Density: 1.373g/cm³
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 381.05757
• Heavy Atom Count: 23
• Complexity: 380

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)O)O)O)O.Br

Technology Process of dl-Laudanosoline hydrobromide

There total 3 articles about dl-Laudanosoline hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

laudanosine (1699-51-0,20412-65-1) → N-methyltetrahydropapaveroline hydrobromide (84030-13-7)

Guidance literature:

With hydrogen bromide; for 0.5h; Heating;

DOI:10.1016/j.phytochem.2005.10.007

Reference yield:

N-methylpapaverinium chloride (19716-71-3) → N-methyltetrahydropapaveroline hydrobromide (84030-13-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 42 percent / NaBH₄ / methanol / 2 h / 20 °C

2: 33 percent / aq. HBr / 0.5 h / Heating

With sodium tetrahydroborate; hydrogen bromide; In methanol;

DOI:10.1016/j.phytochem.2005.10.007

Reference yield:

papaverine hydrochloride (61-25-6) → N-methyltetrahydropapaveroline hydrobromide (84030-13-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methanol; CHCl₃ / 13 h / 110 °C

1.2: 78 percent / AgCl / methanol

2.1: 42 percent / NaBH₄ / methanol / 2 h / 20 °C

3.1: 33 percent / aq. HBr / 0.5 h / Heating

With sodium tetrahydroborate; hydrogen bromide; In methanol; chloroform;

DOI:10.1016/j.phytochem.2005.10.007

upstream raw materials:

laudanosine

N-methylpapaverinium chloride

papaverine hydrochloride

Refernces