2-Methoxy-1-phenylmethoxy-4-prop-1-enylbenzene

Base Information

• Chemical Name: 2-Methoxy-1-phenylmethoxy-4-prop-1-enylbenzene
• CAS No.: 120-11-6
• Molecular Formula: C17H18O2
• Molecular Weight: 254.329
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID0051605
• Mol file: 120-11-6.mol

Synonyms:2-methoxy-1-phenylmethoxy-4-prop-1-enylbenzene;1-(Benzyloxy)-2-methoxy-4-(1-propenyl)benzene;benzyl 2 - methoxy - 4 - prop - 1 - enylphenyl ether;2-METHOXY-1-(PHENYLMETHOXY)-4-(1-PROPENYL)-BENZENE;SCHEMBL873590;BENZENE, 2-METHOXY-1-(PHENYLMETHOXY)-4- (1-PROPENYL)-;DTXSID0051605;AKOS030228023;FT-0631688;FT-0700058

Chemical Property of 2-Methoxy-1-phenylmethoxy-4-prop-1-enylbenzene

Chemical Property:

• Appearance/Colour: White crystalline power
• Vapor Pressure: 6.76E-06mmHg at 25°C
• Melting Point: 59-63 °C(lit.)
• Refractive Index: 1.583
• Boiling Point: 388.638 °C at 760 mmHg
• Flash Point: 152.122 °C
• PSA: 18.46000
• Density: 1.064 g/cm³
• LogP: 4.30730
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 254.130679813
• Heavy Atom Count: 19
• Complexity: 268

Purity/Quality:

99% ^*data from raw suppliers

1-(Benzyloxy)-2-methoxy-4-(prop-1-en-1-yl)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC=CC1=CC(=C(C=C1)OCC2=CC=CC=C2)OC
• Description: Isoeugenyl benzyl ether has a faint, floral odor of rose-carnation. May be synthesized by benzylation of isoeugenol; also by alkaline isomerization of benzyleugenol.

Technology Process of 2-Methoxy-1-phenylmethoxy-4-prop-1-enylbenzene

There total 2 articles about 2-Methoxy-1-phenylmethoxy-4-prop-1-enylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-4-propenylphenol (97-54-1) + benzyl bromide (100-39-0) → 2-methoxy-1-(phenylmethoxy)-4-(1-propenyl)-benzene (120-11-6)

Guidance literature:

2-methoxy-4-propenylphenol; With potassium carbonate; In N,N-dimethyl-formamide; for 2h; Inert atmosphere;

benzyl bromide; In N,N-dimethyl-formamide; at 60 ℃; for 12h;

DOI:10.1021/jo801659g

Reference yield:

2-methoxy-4-propenylphenol (97-54-1) + benzyl chloride (100-44-7) → 2-methoxy-1-(phenylmethoxy)-4-(1-propenyl)-benzene (120-11-6)

Guidance literature:

With sodium ethanolate; In ethanol; Reflux;

DOI:10.1016/j.cbi.2021.109753

Reference yield: 100.0%

2-methoxy-1-(phenylmethoxy)-4-(1-propenyl)-benzene (120-11-6) → 2-methoxy-4-n-propylphenol (2785-87-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; at 20 ℃; for 24h; Neat (no solvent);

DOI:10.1016/j.tet.2011.09.043

upstream raw materials:

2-methoxy-4-propenylphenol

benzyl bromide

benzyl chloride

Downstream raw materials:

2-methoxy-4-(prop-1-enyl)phenyl acetate

1-(benzyloxy)-2-methoxy-4-propylbenzene

2-methoxy-4-n-propylphenol

Refernces

• 1、 Chakraborti, Asit K.,Chankeshwara, Sunay V.. "Counterattack mode differential acetylative deprotection of phenylmethyl ethers: Applications to solid phase organic reactions". supporting information; experimental part. p. 1367 - 1370. Retrieved 2009/07/04.