1-(5-BROMO-THIOPHEN-2-YL)-PROPAN-1-ONE

Base Information

• Chemical Name: 1-(5-BROMO-THIOPHEN-2-YL)-PROPAN-1-ONE
• CAS No.: 32412-39-8
• Molecular Formula: C7H7BrOS
• Molecular Weight: 219.102
• Hs Code.: 2934999090
• Mol file: 32412-39-8.mol

Synonyms:1-(5-Bromothiophen-2-yl)propan-1-one;NSC 80373;5-Bromo-2-thienylethylketone;1-(5-bromo-2-thienyl)-1-propanone;

Chemical Property of 1-(5-BROMO-THIOPHEN-2-YL)-PROPAN-1-ONE

Chemical Property:

• Vapor Pressure: 0.00197mmHg at 25°C
• Refractive Index: 1.57
• Boiling Point: 291.2 °C at 760 mmHg
• Flash Point: 129.9 °C
• PSA: 45.31000
• Density: 1.53 g/cm³
• LogP: 3.10330

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(5-Bromothien-2-yl)propan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-BROMO-THIOPHEN-2-YL)-PROPAN-1-ONE

There total 4 articles about 1-(5-BROMO-THIOPHEN-2-YL)-PROPAN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-bromothiophene (1003-09-4) + propionyl chloride (79-03-8) → 1-(5-bromothiophen-2-yl)propan-1-one (32412-39-8)

Guidance literature:

propionyl chloride; With aluminum (III) chloride; In 1,2-dichloro-ethane; at 0 ℃; for 0.333333h;

2-bromothiophene; In 1,2-dichloro-ethane; at 0 - 20 ℃;

Reference yield:

2-bromothiophene (1003-09-4) + propionic acid anhydride (123-62-6) → 1-(5-bromothiophen-2-yl)propan-1-one (32412-39-8)

Guidance literature:

With boron fluoride ether;

DOI:10.1021/ja01164a103

Reference yield:

2-bromothiophene (1003-09-4) + propionic acid anhydride (123-62-6) → 1-(5-bromothiophen-2-yl)propan-1-one (32412-39-8) + C7H7BrOS

Guidance literature:

With boron trifluoride diethyl etherate; at 100 ℃; for 1h; Overall yield = 60 %; Inert atmosphere;

DOI:10.1002/chem.201500658

upstream raw materials:

2-bromothiophene

propionyl chloride

propionic acid anhydride

Downstream raw materials:

5-(5-bromothiophen-2-yl)-1-(2,4-dichloro-phenyl)-4-methyl-5-thiophen-2-yl-1H-pyrazole-3-carboxylic acid ethyl ester

Refernces

• 1、 Yang, Jingya,Xie, Dongtai,Zhou, Hongyan,Chen, Shuwen,Duan, Jiaokui,Huo, Congde,Li, Zheng. "Visible-Light-Mediated Rose Bengal-Catalyzed α-Hydroxymethylation of Ketones with Methanol". supporting information. p. 3471 - 3476. Retrieved 2018/09/12.
• 2、 Sasaki, Ikuo,Taguchi, Jumpei,Hiraki, Shotaro,Ito, Hajime,Ishiyama, Tatsuo. "Catalyst-controlled regiodivergent C-H borylation of multifunctionalized heteroarenes by using iridium complexes". supporting information. p. 9236 - 9241. Retrieved 2015/06/16.