2-Amino-5-methylthiazole

Base Information

• Chemical Name: 2-Amino-5-methylthiazole
• CAS No.: 7305-71-7
• Molecular Formula: C4H6N2S
• Molecular Weight: 114.171
• Hs Code.: 29341000
• European Community (EC) Number: 423-800-5,615-902-5
• NSC Number: 523150
• UNII: 7RAB78AF2P
• DSSTox Substance ID: DTXSID10223329
• Nikkaji Number: J382.938C
• Wikidata: Q27268750
• ChEMBL ID: CHEMBL502447
• Mol file: 7305-71-7.mol

Synonyms:2-amino-5-methylthiazole;2a5mt cpd

Chemical Property of 2-Amino-5-methylthiazole

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.0588mmHg at 25°C
• Melting Point: 93-98 °C(lit.)
• Refractive Index: 1.618
• Boiling Point: 232.5 °C at 760 mmHg
• PKA: 5.42±0.10(Predicted)
• Flash Point: 94.4 °C
• PSA: 67.15000
• Density: 1.258 g/cm³
• LogP: 1.61490
• Storage Temp.: 2-8°C
• Solubility.: soluble in Methanol
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 114.02516937
• Heavy Atom Count: 7
• Complexity: 66.7

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-5-methylthiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, N, Xi
• Hazard Codes: Xn,N,Xi
• Statements: 22-48/22-50/53-36/37/38
• Safety Statements: 60-61-29-26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C(S1)N
• Uses: An aminothiazole derivative used in characterization and DNA-interaction studies via formation of metal complexes that bind competitively to DNA. 2-Amino-5-methylthiazole can be used in solar cells to influence the interaction with the TiO2 photoelectrode, which in turn alters the dye-sensitized solar cell performance. 2-Amino-5-methylthiazole may be used in the preparation of acrylamide monomer, 5-methyl-2-thiozyl methacrylamide (MTMAAm).

Technology Process of 2-Amino-5-methylthiazole

There total 15 articles about 2-Amino-5-methylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (35511-15-0) + meloxicam (71125-38-7) → 5-methyl-2-thiazol-2-amine (7305-71-7)

Guidance literature:

With montmorillonite MK₁₀ impregnated with ZnCl₂; In o-xylene; for 24h; Reagent/catalyst; Reflux; Green chemistry;

DOI:10.1007/s13738-018-1525-6

Reference yield: 83.0%

potassium thioacyanate (333-20-0) + chloroacetone (78-95-5) → 5-methyl-2-thiazol-2-amine (7305-71-7)

Guidance literature:

With ammonium acetate on neutral alumina; silica gel; In benzene; at 80 ℃; for 6h;

DOI:10.1016/j.tet.2006.01.075

Reference yield: 59.0%

1-isothiocyanatopropa-1,2-diene (137768-73-1) → 5-methyl-2-thiazol-2-amine (7305-71-7)

Guidance literature:

With ammonia;

upstream raw materials:

propan-1-ol

propionaldehyde

thiourea

2-chloropropanal

Downstream raw materials:

5-methyl-1,3-thiazole-2-carbaldehyde

N-(5-methylthiazol-2-yl)acetamide

4-nitro-N-5-methyl-thiazol-2-yl-benzenesulfonamide

N-acetyl-sulfanilic acid-(5-methyl-thiazol-2-ylamide)

Refernces

• 1、 Phukan, Nithi,Baruah, Jubaraj B.. "Detection of Al3 + and Zn2 + ions by 2-(5-methylthiazol-2-yliminomethyl)phenol". . p. 89 - 92. Retrieved 2013.
• 2、 Li, Minghua,Sim, Yoojin,Ham, Seung Wook. "Discovery of 2-aminothiazole derivatives as antitumor agents". scheme or table. p. 1463 - 1464. Retrieved 2010/10/19.